SCHEMBL4608617

SCHEMBL4608617

COC(=O)c1ccc(C(=O)Nc2cccc(C)c2)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.76
RAB9A P51151 5/20 0.76
NPC1 O15118 4/20 0.76
TP53 P04637 4/20 0.76
NFKB1 P19838 1/20 0.76
NFKB2 Q00653 1/20 0.76
RELA Q04206 1/20 0.76
KMT2A Q03164 5/20 0.69
MEN1 O00255 4/20 0.69
RXFP1 Q9HBX9 1/20 0.69
GPR17 Q13304 1/20 0.68
KCNK3 O14649 7/20 0.66
KCNK9 Q9NPC2 3/20 0.64
KCNH2 Q12809 1/20 0.64
POLB P06746 1/20 0.63
ALDH1A1 P00352 3/20 0.61
LMNA P02545 2/20 0.61
TSHR P16473 1/20 0.60
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11710023 0.90 RAB9A (0.76) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL259706 0.87 MEN1 (0.77) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL4610855 0.86 MEN1 (0.72) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL259430 0.86 NPC1 (1.00) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL14363224 0.84 MEN1 (0.73) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL8461683 0.84 MEN1 (0.73) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL29434800 0.83 KCNK3 (0.87) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL259468 0.83 KCNK3 (0.87) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL2908619 0.83 MEN1 (0.89) SMN1; SMN2RAB9ANPC1TP53NFKB1
SCHEMBL23070479 0.83 RAB9A (0.80) SMN1; SMN2RAB9ANPC1TP53KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3757179-A1 INK COMPOSITION FOR INKJET PRINTING, IMAGE FORMING METHOD, AND RECORDED MATERIAL Fujifilm Corporation (JP) 2020-12-30 EP disclosed
US-20200347252-A1 INK COMPOSITION FOR INK JET PRINTING, IMAGE FORMING METHOD, AND RECORDED MATERIAL FUJIFILM CORPORATION (JP) 2020-11-05 US disclosed
EP-3502198-A1 INK FOR INK JET RECORDING, INK JET RECORDING METHOD, INFRARED READING METHOD, AND PRINTED PRODUCT FUJIFILM Corporation (JP) 2019-06-26 EP disclosed
EP-1660437-B1 HYDROXAMIC ACID DERIVATIVES AND THE METHOD FOR PREPARING THEREOF AMOREPACIFIC CORP (KR) 2008-10-15 EP disclosed
US-7282522-B2 Hydroxamic acid derivatives and the method for preparing thereof AMOREPACIFIC CORPORATION (KR) 2007-10-16 US disclosed
US-20060252834-A1 Hydroxamic acid derivatives and the method for preparing thereof AMOREPACIFIC CORPORATION (KR) 2006-11-09 US disclosed
EP-1660437-A4 HYDROXAMIC ACID DERIVATIVES AND THE METHOD FOR PREPARING THEREOF AMOREPACIFIC CORP (KR) 2006-09-20 EP disclosed
EP-1660437-A1 HYDROXAMIC ACID DERIVATIVES AND THE METHOD FOR PREPARING THEREOF Amorepacific Corporation (KR) 2006-05-31 EP disclosed
WO-2005019162-A1 HYDROXAMIC ACID DERIVATIVES AND THE METHOD FOR PREPARING THEREOF AMOREPACIFIC CORPORATION (KR) 2005-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060252834-A1 Hydroxamic acid derivatives and the method for preparing thereof HDAC7, SIRT7, HCAR1 SMN1; SMN2 2940/4885RAB9A 4487/4885NPC1 2347/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.