Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 6/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7318524 | 0.91 | HTR1A (0.62) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7327180 | 0.81 | SIGMAR1 (0.57) | SIGMAR1HTR1ACYP2D6HTR2CHTR7 | |
| SCHEMBL4928965 | 0.80 | SIGMAR1 (0.62) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11465528 | 0.78 | SIGMAR1 (0.76) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7321381 | 0.78 | SIGMAR1 (0.56) | SIGMAR1HTR1ACYP2D6HTR2CHTR7 | |
| Hydrochloric Acid SCHEMBL7323720 | 0.78 | HTR1A (0.53) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3209307 | 0.78 | SIGMAR1 (0.71) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL10520491 | 0.77 | SIGMAR1 (0.56) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9378627 | 0.77 | SIGMAR1 (1.00) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8129982 | 0.77 | SIGMAR1 (0.70) | SIGMAR1HTR1AHTR7DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272187-B1 | DOPAMINE-D3 RECEPTOR LIGANDS FOR THE TREATMENT OF ADDICTION | ABBOTT GMBH & CO KG (DE) | 2008-07-30 | — | — | EP | claimed |
| EP-1272187-B1 | DOPAMINE-D3 RECEPTOR LIGANDS FOR THE TREATMENT OF ADDICTION | ABBOTT GMBH & CO KG (DE) | 2008-07-30 | — | — | EP | disclosed |
| US-20030087917-A1 | Use of dopamine-d3 receptor ligands for the treatment of diseases of the central nervous system | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087917-A1 | Use of dopamine-d3 receptor ligands for the treatment of diseases of the central nervous system | DRD3, DRD2, OPRD1 | SIGMAR1 102/4885HTR1A 111/4885ALDH1A1 1176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.