Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 8/20 | 0.56 |
| ▸ | DRD3 | P35462 | 7/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609182 | 0.80 | SIGMAR1 (0.62) | SIGMAR1DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL4930259 | 0.78 | SIGMAR1 (0.62) | SIGMAR1DRD2DRD3ADRA1ACACNA1G | |
| SCHEMBL9378627 | 0.78 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL5181068 | 0.75 | SIGMAR1 (0.61) | SIGMAR1DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL11465528 | 0.75 | SIGMAR1 (0.76) | SIGMAR1DRD2DRD3ADRA1AHTR1A | |
| Hydrochloric Acid SCHEMBL4925988 | 0.75 | SIGMAR1 (0.60) | SIGMAR1DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL4927353 | 0.74 | SIGMAR1 (0.62) | SIGMAR1DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL9520731 | 0.74 | HTR2C (0.74) | SIGMAR1DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL3209307 | 0.74 | SIGMAR1 (0.71) | SIGMAR1DRD2DRD3ADRA1AHTR1A | |
| Hydrochloric Acid SCHEMBL4929043 | 0.74 | SIGMAR1 (0.61) | SIGMAR1DRD2DRD3ADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432269-B2 | Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents | BIOPROJET (FR) | 2008-10-07 | — | — | US | disclosed |
| US-20080167320-A1 | NOVEL ARYLPIPERAZINE DERIVATIVES | CAPET MARC | 2008-07-10 | — | — | US | disclosed |
| US-20060089364-A1 | Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents | BIOPROJET (FR) | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167320-A1 | NOVEL ARYLPIPERAZINE DERIVATIVES | DRD2, HTR2C, DRD3 | SIGMAR1 134/4885DRD2 1/4885DRD3 3/4885 |
| US-20060089364-A1 | Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents | CYP4Z1, CYP3A5, CYP1A2 | SIGMAR1 911/4885DRD2 1280/4885DRD3 1872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.