Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608310 | 0.90 | CHRNB4 (0.37) | LTA4HNPY1RHTTNPY2RALDH1A1 | |
| SCHEMBL14538699 | 0.83 | LTA4H (0.49) | LTA4HHTT | |
| SCHEMBL15908896 | 0.79 | NPY1R (0.51) | NPY1RHTTNPY2RALDH1A1TSHR | |
| SCHEMBL14538755 | 0.73 | FAAH (0.47) | LTA4HHTTALDH1A1 | |
| SCHEMBL4608914 | 0.73 | SLC6A3 (0.47) | NPY1RHTTNPY2R | |
| SCHEMBL6610063 | 0.71 | LTA4H (0.57) | LTA4H | |
| SCHEMBL4653088 | 0.71 | NPY1R (0.47) | NPY1RHTTNPY2RALDH1A1 | |
| SCHEMBL4653085 | 0.71 | NPY1R (0.47) | NPY1RHTTNPY2RALDH1A1 | |
| SCHEMBL4653089 | 0.71 | NPY1R (0.47) | NPY1RHTTNPY2RALDH1A1 | |
| SCHEMBL4624653 | 0.70 | S1PR1 (0.35) | NPY1RHTTNPY2RS1PR5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | claimed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | claimed |
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |