Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 8/20 | 0.42 |
| ▸ | CA12 | O43570 | 7/20 | 0.42 |
| ▸ | CA1 | P00915 | 7/20 | 0.42 |
| ▸ | CA9 | Q16790 | 7/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4204762 | 0.86 | PKM (0.47) | PKMKDM4ECA2CA12CA1 | |
| SCHEMBL9858695 | 0.84 | ALOX5 (0.43) | PKMKDM4ECA2CA12CA1 | |
| SCHEMBL18261777 | 0.83 | PKM (0.36) | PKMKDM4ECA2CA12CA1 | |
| SCHEMBL4454750 | 0.82 | PTGS2 (0.36) | PKMCA2CA12CA1CA9 | |
| SCHEMBL4608472 | 0.81 | PKM (0.46) | PKMKDM4ECA2CA12CA1 | |
| SCHEMBL4207227 | 0.80 | CA2 (0.49) | PKMKDM4ECA2CA12CA1 | |
| SCHEMBL4609865 | 0.80 | PKM (0.43) | PKMCA2CA12CA1CA9 | |
| Hydrochloric Acid SCHEMBL4609743 | 0.79 | PKM (0.45) | PKMKDM4ECA2CA12CA1 | |
| SCHEMBL3705401 | 0.78 | CA2 (0.47) | PKMCA2CA12CA1CA9 | |
| SCHEMBL28301192 | 0.76 | MAPT (0.50) | PKMKDM4ECA2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976498-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007127505-A2 | USE OF SULFONAMIDE DERIVATIVES IN THE TREATMENT OF DISORDERS OF THE METABOLISM AND THE NERVOUS SYSTEM | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-08 | — | — | WO | disclosed |