Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 15/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342038 | 0.79 | GABRA1 (0.39) | HTR4KMT2AHTR2A | |
| SCHEMBL7304429 | 0.76 | HTT (0.42) | HTR4KMT2AHPGDALDH1A1 | |
| SCHEMBL29805676 | 0.75 | HTR4 (0.55) | HTR4KMT2AHTR2A | |
| SCHEMBL1832626 | 0.75 | HTR4 (0.55) | HTR4KMT2AHTR2A | |
| Hydrochloric Acid SCHEMBL1405875 | 0.74 | HTR4 (0.54) | HTR4KMT2AHTR2A | |
| SCHEMBL29527167 | 0.71 | LDHA (0.39) | HTR4 | |
| SCHEMBL22776609 | 0.71 | LDHA (0.39) | HTR4 | |
| SCHEMBL15635669 | 0.69 | ELANE (0.39) | HTR4KMT2AHPGDHCAR3HCAR2 | |
| SCHEMBL2600883 | 0.68 | KDM4E (0.40) | HTR4KMT2AALDH1A1GAA | |
| SCHEMBL29614427 | 0.68 | KDM4E (0.40) | HTR4KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910340-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | Pfizer, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007010390-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER JAPAN INC. (JP) | 2007-01-25 | — | — | WO | disclosed |