Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 15/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4610481 | 0.79 | HTR4 (0.38) | HTR4HTR2AKMT2A | |
| SCHEMBL29527167 | 0.78 | LDHA (0.39) | HTR4POLB | |
| SCHEMBL22776609 | 0.78 | LDHA (0.39) | HTR4POLB | |
| SCHEMBL7335215 | 0.76 | GABRA1 (0.39) | GABRA1GABRB2MEN1LMNAKMT2A | |
| SCHEMBL7304429 | 0.73 | HTT (0.42) | HTR4MEN1KMT2APOLB | |
| SCHEMBL1832626 | 0.72 | HTR4 (0.55) | HTR4HTR2AKMT2A | |
| SCHEMBL29805676 | 0.72 | HTR4 (0.55) | HTR4HTR2AKMT2A | |
| Hydrochloric Acid SCHEMBL1405875 | 0.71 | HTR4 (0.54) | HTR4HTR2AKMT2A | |
| SCHEMBL23809325 | 0.70 | KDM4E (0.38) | GABRA1GABRB2MEN1LMNAKMT2A | |
| SCHEMBL8876503 | 0.68 | HTR3A (0.38) | HTR4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975623-B1 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | ACRAF (IT) | 2002-06-19 | — | — | EP | disclosed |
| US-6197769-B1 | SEROTONINE RECEPTORS ANTAGONIST; GASTROINTESTINAL DISORDERS, ANTIARRHYTHMIA AGENTS; INCONTINENCE | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2001-03-06 | — | — | US | disclosed |
| EP-0975623-A2 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046589-A2 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 1998-10-22 | — | — | WO | disclosed |