Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 7/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28414251 | 0.96 | GSR (0.44) | GSRCPB2DPP4DPP7DPP8 | |
| Lysine SCHEMBL3135103 | 0.96 | GSR (0.44) | GSRCPB2DPP4DPP7DPP8 | |
| Lysine SCHEMBL27639977 | 0.94 | GSR (0.47) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL659927 | 0.94 | GSR (0.47) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL8205468 | 0.91 | GSR (0.43) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL17685564 | 0.91 | GSR (0.43) | GSRCPB2DPP4DPP7DPP8 | |
| Isoleucine SCHEMBL27660748 | 0.88 | DPP4 (0.37) | DPP4DPP7DPP8DPP9FAP | |
| Isoleucine SCHEMBL4405367 | 0.88 | DPP4 (0.37) | DPP4DPP7DPP8DPP9FAP | |
| Lysine SCHEMBL28801803 | 0.88 | GSR (0.41) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL29054307 | 0.87 | GSR (0.40) | GSRDPP4DPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1498476-B1 | MUTATED ALKALINE CELLULASE | KAO CORP (JP) | 2008-10-15 | — | — | EP | claimed |
| US-7364891-B2 | Mutated alkaline cellulase | KAO CORPORATION (JP) | 2008-04-29 | — | — | US | claimed |
| EP-1498476-B1 | MUTATED ALKALINE CELLULASE | KAO CORP (JP) | 2008-10-15 | — | — | EP | disclosed |
| US-7364891-B2 | Mutated alkaline cellulase | KAO CORPORATION (JP) | 2008-04-29 | — | — | US | disclosed |
| US-20050287656-A1 | Mutated alkaline cellulase | KAO CORPORATION (JP) | 2005-12-29 | — | — | US | disclosed |
| EP-1498476-A1 | MUTATED ALKALINE CELLULASE | Kao Corporation (JP) | 2005-01-19 | — | — | EP | disclosed |