Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27697384 | 0.81 | ANPEP (0.36) | MEN1KMT2AANPEPDPP4 | |
| SCHEMBL7687360 | 0.81 | ANPEP (0.38) | MEN1KMT2AANPEPDPP4CA12 | |
| SCHEMBL11498102 | 0.81 | GABRA1 (0.50) | GABRA1GABRB2AKR1B1LMNAGAA | |
| SCHEMBL4380150 | 0.81 | TYMS (0.49) | GABRA1GABRB2AKR1B1LMNAGAA | |
| SCHEMBL3259476 | 0.81 | GABRA1 (0.46) | GABRA1GABRB2AKR1B1LMNAGAA | |
| SCHEMBL10582948 | 0.79 | CASP3 (0.55) | GABRA1GABRB2AKR1B1LMNAGAA | |
| SCHEMBL4379341 | 0.78 | CYP1B1 (0.49) | GABRA1GABRB2AKR1B1LMNAGAA | |
| SCHEMBL5824091 | 0.72 | GABRA1 (0.58) | GABRA1GABRB2AKR1B1LMNAGAA | |
| SCHEMBL461695 | 0.71 | GABRA1 (0.50) | GABRA1GABRB2AKR1B1LMNAGAA | |
| SCHEMBL38652483 | 0.71 | GABRA1 (0.50) | GABRA1GABRB2AKR1B1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236122-B2 | Triterpene amine derivatives | DFH THERAPEUTICS (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210253627-A1 | TRITERPENE AMINE DERIVATIVES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-08-19 | — | — | US | disclosed |
| US-9260473-B2 | Bivalent multifunctional ligands targeting Aβ oligomers as treatment for Alzheimer's disease | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2016-02-16 | — | — | US | disclosed |
| US-8895558-B2 | Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders | GREEN CROSS CORPORATION (KR) | 2014-11-25 | — | — | US | disclosed |
| US-8492384-B2 | Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-07-23 | — | — | US | disclosed |
| US-20130156705-A1 | BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING A[BETA] OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2013-06-20 | — | — | US | disclosed |
| WO-2012012257-A2 | BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING Aβ OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2012-01-26 | — | — | WO | disclosed |
| US-20110178091-A1 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | GREEN CROSS CORPORATION (KR) | 2011-07-21 | — | — | US | disclosed |
| EP-2311824-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | Aventis Pharmaceuticals Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| WO-2010038948-A2 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | GREEN CROSS CORPORATION (KR) | 2010-04-08 | — | — | WO | disclosed |
| US-5550130-A | ANTIPSYCHOTIC AGENTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0686642-A2 | Modified guanidino and amidino thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-12-13 | — | — | EP | disclosed |
| WO-1995011680-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-05-04 | — | — | WO | disclosed |
| EP-0623595-A1 | Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-09 | — | — | EP | disclosed |
| EP-0087853-B1 | 4-DIPHENYLMETHYL-1-(OXOALKYL)IMINO)METHYL-PIPERIDINES AND THEIR DERIVATIVES | McNeilab, Inc. (US) | 1986-04-30 | — | — | EP | disclosed |
| EP-0087853-A2 | 4-Diphenylmethyl-1-(oxoalkyl)imino)methyl-piperidines and their derivatives | McNeilab, Inc. (US) | 1983-09-07 | — | — | EP | disclosed |
| US-4370335-A | Antisecretory 4-diphenylmethyl-1-[(oxoalkyl)imino]methyl-piperidines and their derivatives | MCNEILAB, INC. (US) | 1983-01-25 | — | — | US | disclosed |
| US-4211703-A | CHEMICAL INTERMEDIATES FOR CEPHALOSPORINS | SMITHKLINE CORPORATION (US) | 1980-07-08 | — | — | US | disclosed |
| US-4189573-A | CHEMICAL INTERMEDIATES | SMITHKLINE CORPORATION (US) | 1980-02-19 | — | — | US | disclosed |
| US-4112086-A | BACTERICIDE | SMITHKLINE CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253627-A1 | TRITERPENE AMINE DERIVATIVES | BET1, PGGT1B, NFATC1 | GABRA1 1735/4885GABRB2 3214/4885AKR1B1 3480/4885 |
| US-20110178091-A1 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | NPY5R, TPH2, MC5R | GABRA1 488/4885GABRB2 474/4885AKR1B1 1495/4885 |
| US-11236122-B2 | Triterpene amine derivatives | BET1, PGGT1B, NFATC1 | GABRA1 1735/4885GABRB2 3214/4885AKR1B1 3480/4885 |
| US-20130156705-A1 | BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING A[BETA] OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE | LDLR, NR1H2, MSR1 | GABRA1 345/4885GABRB2 200/4885AKR1B1 645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.