Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | THRB | P10828 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4614810 | 0.79 | NOS1 (0.42) | ALDH1A1THRBALOX15CASP1HSD17B10 | |
| SCHEMBL6316444 | 0.74 | PTPN1 (0.50) | ALDH1A1CYP3A4CASP1HSD17B10HPGD | |
| SCHEMBL4614202 | 0.73 | ALDH1A1 (0.50) | ALDH1A1THRBCYP3A4TSHRALOX15 | |
| SCHEMBL2667905 | 0.72 | MAP4K4 (0.49) | ALDH1A1CYP3A4CASP1HSD17B10HPGD | |
| SCHEMBL4612733 | 0.70 | MAPT (0.35) | ALDH1A1THRBCYP3A4TSHRALOX15 | |
| SCHEMBL457582 | 0.68 | HSP90AA1 (0.43) | ALDH1A1TSHRHSD17B10RECQLKDM4E | |
| SCHEMBL3338155 | 0.67 | CASP1 (0.46) | ALDH1A1THRBCYP3A4TSHRALOX15 | |
| Hydrochloric Acid SCHEMBL4612966 | 0.67 | HSP90AA1 (0.42) | ALDH1A1TSHRHSD17B10RECQLKDM4E | |
| SCHEMBL7086514 | 0.67 | IDO1 (0.46) | ALDH1A1THRBCYP3A4TSHRALOX15 | |
| SCHEMBL7086055 | 0.67 | PIK3CD (0.52) | ALDH1A1THRBCYP3A4TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351945-B1 | NOVEL 1,4-DIAMINO-2-(THIAZOL-2-YL)BENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS | WELLA AG (DE) | 2008-01-23 | — | — | EP | disclosed |
| US-6875873-B2 | 1,4-Diamino-2-(thiazol-2-yl)benzene derivatives, and dyes containing said compounds | WELLA AKTIENGESELLSCHAFT (DE) | 2005-04-05 | — | — | US | disclosed |
| US-20030115683-A1 | Novel 1,4-diamino-2-(thiazol-2-yl)benzene derivatives and dyes containing said compounds | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030115683-A1 | Novel 1,4-diamino-2-(thiazol-2-yl)benzene derivatives and dyes containing said compounds | KRT18, DSP, TUBB1 | ALDH1A1 20/4885THRB 2455/4885CYP3A4 992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.