Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4611623 | 0.80 | L3MBTL1 (0.56) | MC4RL3MBTL1HRH3SIGMAR1SLC6A3 | |
| SCHEMBL4168502 | 0.80 | KDM4E (0.52) | MC4RHRH3SIGMAR1CXCR3HTR1A | |
| SCHEMBL4611997 | 0.77 | L3MBTL1 (0.53) | L3MBTL1 | |
| SCHEMBL13476455 | 0.76 | SLC6A4 (0.59) | SIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL13150832 | 0.73 | KMT2A (0.79) | MC4RHRH3SIGMAR1SLC6A4PKM | |
| SCHEMBL6056974 | 0.71 | SLC6A3 (0.83) | SIGMAR1SLC6A3HTR1ADRD2 | |
| SCHEMBL14407778 | 0.71 | SLC6A3 (0.83) | SIGMAR1SLC6A3HTR1ADRD2 | |
| SCHEMBL7264546 | 0.71 | SLC6A3 (0.83) | SIGMAR1SLC6A3HTR1ADRD2 | |
| SCHEMBL13150782 | 0.71 | SLC6A3 (0.83) | SIGMAR1SLC6A3HTR1ADRD2 | |
| SCHEMBL287051 | 0.70 | KCNJ1 (0.68) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981849-A1 | HETEROCYCLIC COMPOUNDS | LEK Pharmaceuticals D.D. (SI) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007073935-A1 | HETEROCYCLIC COMPOUNDS | LEK PHARMACEUTICALS D.D. (SI) | 2007-07-05 | — | — | WO | disclosed |