Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618073 | 0.93 | ALDH1A1 (0.62) | POLBALDH1A1TDP1KMT2ASFRP1 | |
| SCHEMBL4618720 | 0.90 | SFRP1 (0.73) | POLBALDH1A1TDP1SFRP1HTR7 | |
| SCHEMBL13045322 | 0.89 | KMT2A (0.76) | POLBALDH1A1TDP1KMT2ANPSR1 | |
| SCHEMBL4638749 | 0.87 | SFRP1 (0.66) | POLBALDH1A1TDP1KMT2ASFRP1 | |
| SCHEMBL4616665 | 0.87 | SFRP1 (0.65) | POLBALDH1A1TDP1SFRP1HTR7 | |
| SCHEMBL4618034 | 0.84 | SFRP1 (0.60) | POLBALDH1A1TDP1KMT2ASFRP1 | |
| SCHEMBL8292850 | 0.82 | TDP1 (0.68) | POLBALDH1A1TDP1KMT2ANPSR1 | |
| SCHEMBL4617661 | 0.81 | SFRP1 (0.61) | ALDH1A1SFRP1NPSR1KDM4EHTR7 | |
| SCHEMBL3719058 | 0.81 | PKM (0.69) | POLBALDH1A1KMT2AHTR7 | |
| SCHEMBL23718088 | 0.80 | L3MBTL1 (0.80) | POLBALDH1A1TDP1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | POLB 4876/4885ALDH1A1 1865/4885TDP1 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.