Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.41 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.41 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.36 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462427 | 0.85 | CYP1A2 (0.43) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| Trifluoroacetic Acid SCHEMBL18497445 | 0.82 | SLC6A1 (0.41) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| Trifluoroacetic Acid SCHEMBL29261408 | 0.81 | SLC6A1 (0.35) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL42348 | 0.78 | GNAO1 (0.49) | ITGB3ITGA2BF2RCYP1A2 | |
| SCHEMBL9673816 | 0.77 | CYP1A2 (0.42) | CYP1A2KMT2ACPN1CPB2 | |
| SCHEMBL9676384 | 0.77 | CYP1A2 (0.42) | CYP1A2KMT2ACPN1CPB2 | |
| Hydrochloric Acid SCHEMBL4424002 | 0.77 | GNAO1 (0.51) | CHRM3CHRM2CHRM1CYP1A2 | |
| SCHEMBL640737 | 0.77 | GNAO1 (0.50) | ITGB3ITGA2BCYP1A2 | |
| Trifluoroacetic Acid SCHEMBL3451505 | 0.76 | SLC6A1 (0.52) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL10917426 | 0.75 | GNAO1 (0.36) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890697-B1 | AZINONE AND DIAZINONE V3 INHIBITORS FOR DEPRESSION AND STRESS DISORDERS | PHARMACOPEIA LLC (US) | 2015-03-04 | — | — | EP | disclosed |
| CN-101212969-B | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA DRUG DISCOVERY | 2013-08-07 | — | — | CN | disclosed |
| US-8350043-B2 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| CN-101212969-A | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA DRUG DISCOVERY (US) | 2008-07-02 | — | — | CN | disclosed |
| EP-1890697-A2 | AZINONE AND DIAZINONE V3 INHIBITORS FOR DEPRESSION AND STRESS DISORDERS | PHARMACOPEIA, INC. (US) | 2008-02-27 | — | — | EP | disclosed |
| US-20070037822-A1 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| WO-2006133242-A2 | AZINONE AND DIAZINONE V3 INHIBITORS FOR DEPRESSION AND STRESS DISORDERS | PHARMACOPEIA, INC. (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037822-A1 | Azinone and diazinone V3 inhibitors for depression and stress disorders | HTR3C, HTR3A, AZI2 | SLC6A1 2287/4885GABRA5 428/4885GABRB2 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.