Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.52 |
| ▸ | MMP2 | P08253 | 9/20 | 0.49 |
| ▸ | MMP9 | P14780 | 8/20 | 0.49 |
| ▸ | MMP12 | P39900 | 3/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 7/20 | 0.45 |
| ▸ | MMP1 | P03956 | 6/20 | 0.45 |
| ▸ | MMP3 | P08254 | 6/20 | 0.45 |
| ▸ | MMP7 | P09237 | 4/20 | 0.45 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4926895 | 1.00 | ADAMTS4 (0.52) | ADAMTS4MMP2MMP9MMP12MMP8 | |
| SCHEMBL4934557 | 1.00 | ADAMTS4 (0.52) | ADAMTS4MMP2MMP9MMP12MMP8 | |
| SCHEMBL4617985 | 0.82 | S1PR1 (0.45) | MMP2MMP9PTGS2MMP3S1PR1 | |
| SCHEMBL4617666 | 0.81 | PTGS2 (0.54) | MMP2PTGS2MMP3S1PR1S1PR3 | |
| SCHEMBL4923643 | 0.80 | PTGS2 (0.45) | MMP2MMP9PTGS2MMP3S1PR1 | |
| SCHEMBL13037379 | 0.79 | MMP2 (0.60) | ADAMTS4MMP2MMP9MMP12MMP8 | |
| SCHEMBL4618310 | 0.76 | NPC1 (0.53) | PTGS2S1PR1S1PR3 | |
| SCHEMBL4619710 | 0.75 | S1PR1 (0.49) | S1PR1S1PR3 | |
| SCHEMBL4618874 | 0.75 | S1PR1 (0.52) | PTGS2S1PR1S1PR3 | |
| SCHEMBL4618489 | 0.74 | AKR1C3 (0.48) | PTGS2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306124-A1 | Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands | NOVARTIS AG (CH) | 2008-12-11 | — | — | US | disclosed |
| EP-1893591-A1 | POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS | Novartis AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006131336-A1 | POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS | NOVARTIS AG (CH) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306124-A1 | Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands | SOX18, SIGMAR1, SUCNR1 | ADAMTS4 4807/4885MMP2 3980/4885MMP9 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.