Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | ARG2 | P78540 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4587301 | 0.79 | ARG1 (0.35) | ARG1ARG2 | |
| SCHEMBL4586313 | 0.77 | ARG1 (0.36) | PTGS2ARG1ARG2 | |
| SCHEMBL14571832 | 0.77 | PTGS2 (0.35) | PTGS1PTGS2ARG1ARG2 | |
| SCHEMBL4587098 | 0.77 | ARG1 (0.33) | ARG1ARG2 | |
| SCHEMBL5151428 | 0.77 | PTGS1 (0.37) | PTGS1PTGS2 | |
| SCHEMBL4586374 | 0.75 | TLR2 (0.32) | ARG1ARG2 | |
| SCHEMBL4588024 | 0.75 | BHMT (0.33) | PTGS1PTGS2ARG1ARG2 | |
| SCHEMBL4587534 | 0.73 | ALDH1A1 (0.34) | ARG1ARG2 | |
| SCHEMBL4588055 | 0.72 | PTGS1 (0.33) | PTGS1PTGS2 | |
| SCHEMBL4586699 | 0.72 | PTGS1 (0.33) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692107-A4 | NITRIC OXIDE RELEASING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2008-10-29 | — | — | EP | claimed |
| EP-1692107-A2 | NITRIC OXIDE RELEASING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005060603-A2 | NITRIC OXIDE RELEASING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2005-07-07 | — | — | WO | claimed |