Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618009 | 0.87 | HTR6 (0.42) | HTR6ALDH1A1HSD17B10TDP1PSIP1 | |
| SCHEMBL8600785 | 0.83 | HTR6 (0.47) | HTR6PSIP1KMT2AHSD11B1PTGDR2 | |
| SCHEMBL4616548 | 0.78 | ALDH1A1 (0.58) | HTR6ALDH1A1HSD17B10TDP1KMT2A | |
| SCHEMBL4618048 | 0.77 | HTR6 (0.49) | HTR6ALDH1A1HSD17B10TDP1KMT2A | |
| SCHEMBL27733563 | 0.77 | HSD11B1 (0.55) | HTR6ALDH1A1HSD17B10TDP1PSIP1 | |
| SCHEMBL27143889 | 0.75 | AKR1B1 (0.38) | ALDH1A1HSD17B10TDP1KMT2AHSD11B1 | |
| SCHEMBL4616216 | 0.75 | HTR6 (0.50) | HTR6ALDH1A1HSD17B10TDP1KMT2A | |
| SCHEMBL11760126 | 0.75 | HTR6 (0.50) | HTR6ALDH1A1HSD17B10TDP1KMT2A | |
| Methyl Phosphonate SCHEMBL1396499 | 0.75 | HSD11B1 (0.44) | HTR6HSD11B1PTGDR2L3MBTL1SLC6A2 | |
| SCHEMBL10181290 | 0.74 | HSD11B1 (0.59) | HTR6PSIP1KMT2AHSD11B1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | HTR6 3789/4885ALDH1A1 1865/4885HSD17B10 1319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.