SCHEMBL4619973

SCHEMBL4619973

COc1ccc(S(=O)(=O)N[C@@H](C)C(=O)O)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 10/20 0.68
MMP9 P14780 7/20 0.68
MMP13 P45452 6/20 0.68
MMP1 P03956 5/20 0.68
MMP8 P22894 5/20 0.68
MMP3 P08254 4/20 0.68
MMP7 P09237 4/20 0.68
SLC1A3 P43003 1/20 0.65
SLC1A2 P43004 1/20 0.65
SLC1A1 P43005 1/20 0.65
ADAMTS4 O75173 2/20 0.65
HSD17B10 Q99714 4/20 0.60
CA12 O43570 2/20 0.59
CA9 Q16790 2/20 0.59
CA14 Q9ULX7 2/20 0.59
ALDH1A1 P00352 2/20 0.57
HPGD P15428 2/20 0.57
KDM4E B2RXH2 1/20 0.57
USP2 O75604 1/20 0.57
TSHR P16473 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4618694 1.00 MMP2 (0.68) MMP2MMP9MMP13MMP1MMP8
SCHEMBL4621342 1.00 MMP2 (0.68) MMP2MMP9MMP13MMP1MMP8
SCHEMBL6329696 0.87 HSD17B10 (0.60) MMP2MMP9MMP13MMP1MMP8
SCHEMBL6329698 0.87 HSD17B10 (0.60) MMP2MMP9MMP13MMP1MMP8
SCHEMBL29541363 0.87 HSD17B10 (0.60) MMP2MMP9MMP13MMP1MMP8
SCHEMBL14218172 0.85 ADAMTS4 (0.63) MMP2MMP9MMP13MMP1MMP8
SCHEMBL7417565 0.84 MMP9 (0.64) MMP2MMP9MMP13MMP1MMP8
SCHEMBL14217417 0.84 MMP9 (0.74) MMP2MMP9MMP13MMP1MMP3
SCHEMBL2161549 0.84 MMP9 (0.92) MMP2MMP9MMP13MMP1MMP8
SCHEMBL2161452 0.84 MMP9 (0.92) MMP2MMP9MMP13MMP1MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020150446-A1 SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2020-07-23 WO disclosed
EP-1884230-A1 PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT OR AGENT FOR PREVENTING/AMELIORATING ROUGH SKIN AND EXTERNAL COMPOSITION FOR SKIN Shiseido Company, Limited (JP) 2008-02-06 EP disclosed
US-4113463-A BENZENESULFONAMIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1978-09-12 US disclosed
US-4070176-A WITH A BENZENESULFONAMIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1978-01-24 US disclosed