Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.74 |
| ▸ | ADAMTS4 | O75173 | 6/20 | 0.70 |
| ▸ | MMP13 | P45452 | 8/20 | 0.65 |
| ▸ | MMP2 | P08253 | 7/20 | 0.65 |
| ▸ | MMP3 | P08254 | 6/20 | 0.65 |
| ▸ | MMP1 | P03956 | 4/20 | 0.65 |
| ▸ | MMP7 | P09237 | 3/20 | 0.65 |
| ▸ | TARS1 | P26639 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798546 | 0.88 | MMP9 (0.67) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL1798547 | 0.88 | MMP9 (0.67) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL1800247 | 0.87 | MMP13 (0.76) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL1800250 | 0.87 | MMP13 (0.76) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL702793 | 0.85 | ADAMTS4 (0.81) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL790069 | 0.85 | ADAMTS4 (0.81) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL702794 | 0.85 | ADAMTS4 (0.81) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL4621342 | 0.84 | MMP2 (0.68) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL4618694 | 0.84 | MMP2 (0.68) | MMP9ADAMTS4MMP13MMP2MMP3 | |
| SCHEMBL4619973 | 0.84 | MMP2 (0.68) | MMP9ADAMTS4MMP13MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |