SCHEMBL7417565

SCHEMBL7417565

COc1ccc(S(=O)(=O)N[C@H](C)C(=O)NO)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 8/20 0.64
MMP1 P03956 6/20 0.64
MMP13 P45452 6/20 0.64
HSD17B10 Q99714 4/20 0.64
ADAM17 P78536 2/20 0.64
SMN1; SMN2 Q16637 2/20 0.62
ALDH1A1 P00352 2/20 0.62
HPGD P15428 2/20 0.62
KDM4E B2RXH2 1/20 0.62
USP2 O75604 1/20 0.62
TSHR P16473 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
POLB P06746 1/20 0.61
HTT P42858 1/20 0.61
MMP2 P08253 6/20 0.58
MMP8 P22894 2/20 0.58
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58
MMP3 P08254 2/20 0.57
MMP7 P09237 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7375998 0.85 MMP9 (0.74) MMP9MMP1MMP13ADAM17MMP2
SCHEMBL7376000 0.85 MMP9 (0.74) MMP9MMP1MMP13ADAM17MMP2
SCHEMBL6329698 0.84 HSD17B10 (0.60) MMP9MMP1MMP13HSD17B10SMN1; SMN2
SCHEMBL6329696 0.84 HSD17B10 (0.60) MMP9MMP1MMP13HSD17B10SMN1; SMN2
SCHEMBL4619973 0.84 MMP2 (0.68) MMP9MMP1MMP13HSD17B10SMN1; SMN2
SCHEMBL4618694 0.84 MMP2 (0.68) MMP9MMP1MMP13HSD17B10SMN1; SMN2
SCHEMBL4621342 0.84 MMP2 (0.68) MMP9MMP1MMP13HSD17B10SMN1; SMN2
SCHEMBL29541363 0.84 HSD17B10 (0.60) MMP9MMP1MMP13HSD17B10SMN1; SMN2
SCHEMBL1800247 0.84 MMP13 (0.76) MMP9MMP1MMP13HSD17B10ADAM17
SCHEMBL1800250 0.84 MMP13 (0.76) MMP9MMP1MMP13HSD17B10ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6218389-B1 FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES THE PROCTER & GAMBLE CO. 2001-04-17 US disclosed
EP-1009737-A2 SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 2000-06-21 EP disclosed
WO-1999006340-A2 SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 1999-02-11 WO disclosed