Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13766486 | 0.80 | MAPT (0.44) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL46709 | 0.77 | XPA (0.51) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL21337609 | 0.76 | TDP1 (0.47) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL28373067 | 0.71 | KEAP1 (0.79) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL28373071 | 0.71 | KEAP1 (0.79) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL2557746 | 0.70 | KDM4E (1.00) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL46230 | 0.70 | MAPT (0.50) | KDM4EPOLBMEN1KMT2ANPC1 | |
| SCHEMBL21292800 | 0.70 | PHGDH (0.75) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL21292802 | 0.70 | PHGDH (0.75) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL28376711 | 0.67 | SIRT5 (0.85) | TDP1KDM4EPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012005800-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | ADHAERE PHARAMACEUTICALS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |