Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.46 |
| ▸ | ITGAM | P11215 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12279902 | 0.71 | MAPT (0.71) | MAPTTP53ITGB2ITGAMKDM4E | |
| SCHEMBL46214 | 0.70 | TDP1 (0.52) | MAPTTP53KDM4ENPC1RAB9A | |
| SCHEMBL13766486 | 0.70 | MAPT (0.44) | MAPTTP53KDM4ENPC1RAB9A | |
| SCHEMBL13087220 | 0.69 | HRH1 (0.49) | MAPTTP53ITGB2ITGAMKDM4E | |
| SCHEMBL46709 | 0.68 | XPA (0.51) | MAPTKDM4ENPC1RAB9AHPGD | |
| SCHEMBL46558 | 0.63 | ITGB2 (1.00) | MAPTITGB2ITGAMNPC1RAB9A | |
| SCHEMBL68989 | 0.63 | HIF1A (0.58) | TP53NPC1RAB9AHPGDPOLB | |
| SCHEMBL7409566 | 0.63 | ALDH1A1 (0.53) | MAPTTP53ITGB2ITGAMKDM4E | |
| SCHEMBL19265224 | 0.63 | ALOX5 (0.53) | MAPTTP53KDM4ENPC1RAB9A | |
| SCHEMBL14667461 | 0.63 | MAPT (0.55) | MAPTTP53KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012005800-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | ADHAERE PHARAMACEUTICALS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |