Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 6/20 | 0.49 |
| ▸ | CA2 | P00918 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185509 | 0.82 | PARP1 (0.53) | MAPTPARP1CES2CES1HSD11B1 | |
| SCHEMBL4163523 | 0.80 | MMP12 (0.50) | MAPTTSHRPARP1CES1KDM4E | |
| SCHEMBL7674553 | 0.79 | HSD11B1 (0.57) | MAPTCA1CA2TSHRPDE4B | |
| SCHEMBL4173740 | 0.78 | MEP1B (0.67) | MAPTCA1CA2TSHRHTT | |
| SCHEMBL1732559 | 0.74 | HTT (0.72) | MAPTCA2TSHRHTTCA12 | |
| SCHEMBL4622173 | 0.74 | CA1 (0.47) | CA1CA2PARP1PARP10PARP2 | |
| SCHEMBL4621268 | 0.74 | CA1 (0.47) | CA1CA2PARP1PARP10PARP2 | |
| SCHEMBL4620575 | 0.74 | CA1 (0.47) | CA1CA2PARP1PARP10PARP2 | |
| SCHEMBL4621422 | 0.74 | CA2 (0.46) | CA1CA2PARP1PARP10PARP2 | |
| SCHEMBL4620569 | 0.74 | CA2 (0.46) | CA1CA2PARP1PARP10PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1884230-A1 | PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT OR AGENT FOR PREVENTING/AMELIORATING ROUGH SKIN AND EXTERNAL COMPOSITION FOR SKIN | Shiseido Company, Limited (JP) | 2008-02-06 | — | — | EP | disclosed |