Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227590 | 0.84 | METAP2 (0.57) | KMT2ANPC1MEN1AGTR1METAP2 | |
| SCHEMBL4626479 | 0.79 | ALDH1A1 (0.47) | KMT2ANPC1MEN1HSP90AA1AGTR1 | |
| SCHEMBL4626576 | 0.78 | MEN1 (0.56) | KMT2ANPC1MEN1AGTR1METAP2 | |
| SCHEMBL4619472 | 0.77 | METAP2 (0.50) | KMT2ANPC1MEN1HSP90AA1AGTR1 | |
| SCHEMBL4624293 | 0.77 | KDM4E (0.49) | KMT2ANPC1MEN1HSP90AA1AGTR1 | |
| SCHEMBL1043719 | 0.74 | METAP2 (0.58) | KMT2ANPC1MEN1HSP90AA1AGTR1 | |
| SCHEMBL30457998 | 0.73 | METAP2 (0.56) | KMT2ANPC1MEN1HSP90AA1AGTR1 | |
| SCHEMBL31157799 | 0.73 | METAP2 (0.56) | KMT2ANPC1MEN1HSP90AA1AGTR1 | |
| SCHEMBL29040602 | 0.73 | METAP2 (0.56) | KMT2ANPC1MEN1HSP90AA1AGTR1 | |
| SCHEMBL11817511 | 0.73 | KDM4E (0.56) | KMT2ANPC1MEN1METAP2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501801-B1 | 2,6-QUINOLINYL AND 2,6-NAPHTHYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF VLA-4 DEPENDENT DISEASES | UCB PHARMA SA (BE) | 2008-01-23 | — | — | EP | claimed |