SCHEMBL4624841

SCHEMBL4624841

CC/C(=C(/C)C(=O)O)c1cccc2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.53
NR4A2 P43354 1/20 0.53
NR4A3 Q92570 1/20 0.53
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
CDC25B P30305 2/20 0.47
PTPN1 P18031 1/20 0.47
PLK1 P53350 1/20 0.47
KDM4E B2RXH2 3/20 0.45
ALDH1A1 P00352 3/20 0.45
MAPT P10636 3/20 0.45
GMNN O75496 2/20 0.45
LMNA P02545 2/20 0.45
POLB P06746 2/20 0.45
HPGD P15428 2/20 0.45
MAPK1 P28482 2/20 0.45
BLM P54132 2/20 0.45
PMP22 Q01453 2/20 0.45
NPSR1 Q6W5P4 2/20 0.45
CMKLR1 Q99788 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11909813 0.80 NR4A1 (0.60) NR4A1NR4A2NR4A3MEN1KMT2A
SCHEMBL5082384 0.80 NR4A1 (0.60) NR4A1NR4A2NR4A3MEN1KMT2A
SCHEMBL6989993 0.80 NR4A1 (0.60) NR4A1NR4A2NR4A3MEN1KMT2A
SCHEMBL28419366 0.78 CLCN2 (0.41) ALDH1A1LMNAALOX15TSHR
SCHEMBL6189630 0.78 ALDH1A1 (0.52) ALDH1A1POLBHPGDCYP1A2TP53
SCHEMBL11350671 0.77 KDM4E (0.51) NR4A1NR4A2NR4A3MEN1KMT2A
SCHEMBL28376850 0.76 NR4A1 (0.47) NR4A1NR4A2NR4A3MEN1KMT2A
SCHEMBL2124452 0.75 PTPN1 (0.67) NR4A1NR4A2NR4A3MEN1KMT2A
SCHEMBL29473553 0.75 PTPN1 (0.67) NR4A1NR4A2NR4A3MEN1KMT2A
SCHEMBL6514661 0.75 PTPN1 (0.53) NR4A1NR4A2NR4A3MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1448571-B1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS BAUSCH & LOMB (US) 2008-05-21 EP claimed
US-7169874-B2 High refractive index polymeric siloxysilane compositions BAUSCH & LOMB INCORPORATED (US) 2007-01-30 US claimed
US-6908978-B2 High refractive index polymeric siloxysilane compositions BAUSCH & LOMB INCORPORATED (US) 2005-06-21 US claimed
US-20050085611-A1 High refractive index aromatic-based siloxane difunctional macromonomers BAUSCH & LOMB MEXICO, S.A. DE C.V. (MX) 2005-04-21 US claimed
EP-1465903-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2004-10-13 EP claimed
EP-1448572-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2004-08-25 EP claimed
EP-1448571-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 2004-08-25 EP claimed
EP-1446409-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE DIFUNCTIONAL MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 2004-08-18 EP claimed
US-20040087753-A1 High refractive index aromatic-based siloxane monofuntional macromonomers SOLTA MEDICAL, INC. 2004-05-06 US claimed
US-20040087678-A1 High refractive index aromatic-based siloxane monofunctional macromonomers PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.) (PL) 2004-05-06 US claimed
US-20040059080-A1 High refractive index aromatic-based siloxane difunctional macromonomers SALAMONE JOSEPH C (US) 2004-03-25 US claimed
US-20030144451-A1 High refractive index aromatic-based siloxane difunctional macromonomers BAUSCH HEALTH US, LLC 2003-07-31 US claimed
US-20030139557-A1 High refractive index aromatic-based siloxane monofunctional macromonomers PRECISION DERMATOLOGY, INC. 2003-07-24 US claimed
US-20030109661-A1 High refractive index polymeric siloxysilane compositions BAUSCH HEALTH US, LLC 2003-06-12 US claimed
US-20030100697-A1 High refractive index polymeric siloxysilane compositions SALIX PHARMACEUTICALS, INC. 2003-05-29 US claimed
WO-2003040154-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE DIFUNCTIONAL MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040157-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040158-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040155-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
EP-0808855-B1 Fluorescent polymers and coating compositions ROHM & HAAS (US) 2002-07-17 EP claimed