Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111786 | 0.98 | MAOA (0.47) | DRD1DRD2DRD4DRD5MAOA | |
| SCHEMBL29803269 | 0.98 | MAOA (0.47) | DRD1DRD2DRD4DRD5MAOA | |
| SCHEMBL16900582 | 0.86 | ALDH1A1 (0.49) | DRD1DRD2DRD4DRD5MAOA | |
| SCHEMBL13957980 | 0.82 | AR (0.40) | DRD1DRD2DRD4DRD5MAOA | |
| SCHEMBL28104564 | 0.77 | ESR1 (0.35) | DRD1DRD2DRD4DRD5MAOA | |
| Bromide SCHEMBL9480957 | 0.75 | DRD2 (0.40) | DRD1DRD2DRD4DRD5MAOA | |
| SCHEMBL16687894 | 0.74 | AR (0.41) | KDM4EMAPTBLMPMP22SMN1; SMN2 | |
| SCHEMBL5501377 | 0.73 | DRD2 (0.56) | DRD1DRD2DRD4DRD5MAPT | |
| SCHEMBL93622 | 0.73 | DRD1 (0.56) | DRD1DRD2DRD4DRD5DRD3 | |
| Bromide SCHEMBL9480751 | 0.73 | DRD2 (0.40) | DRD1DRD2DRD4DRD5MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1234569-B1 | COMPOSITIONS FOR DYEING KERATIN FIBRES | LION CORP (JP) | 2008-07-02 | — | — | EP | disclosed |
| US-6958080-B2 | Compositions for dyeing keratinous fiber | LION CORPORATION (JP) | 2005-10-25 | — | — | US | disclosed |
| EP-1234569-A1 | COMPOSITIONS FOR DYEING HORNY FIBERS | Lion Corporation (JP) | 2002-08-28 | — | — | EP | disclosed |
| EP-1142562-A1 | HAIR DYE COMPOSITIONS | Lion Corporation (JP) | 2001-10-10 | — | — | EP | disclosed |
| EP-1142561-A1 | HAIR DYE COMPOSITIONS | Lion Corporation (JP) | 2001-10-10 | — | — | EP | disclosed |