Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108725 | 0.98 | GPR35 (0.42) | GPR35TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29803617 | 0.98 | GPR35 (0.42) | GPR35TUBB4ATUBBTUBA3CTUBA1B | |
| Hydrochloric Acid SCHEMBL4625202 | 0.96 | GPR35 (0.41) | GPR35TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6941609 | 0.90 | HTR2A (0.40) | GPR35TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29670034 | 0.83 | HTR2A (0.42) | GPR35TNFHTR2AHTR2CMTNR1A | |
| SCHEMBL108285 | 0.83 | HTR2A (0.42) | GPR35TNFHTR2AHTR2CMTNR1A | |
| SCHEMBL29915749 | 0.80 | ALDH1A1 (0.43) | TNFHTR2AHTR2CMTNR1AMTNR1B | |
| SCHEMBL111621 | 0.80 | ALDH1A1 (0.43) | TNFHTR2AHTR2CMTNR1AMTNR1B | |
| Quinoline SCHEMBL27735431 | 0.80 | ALDH1A1 (0.45) | CYP19A1MTNR1AKDM4EMEN1MAPT | |
| SCHEMBL1881998 | 0.78 | CDK4 (0.46) | TNFHTR2AHTR2CKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1234569-B1 | COMPOSITIONS FOR DYEING KERATIN FIBRES | LION CORP (JP) | 2008-07-02 | — | — | EP | disclosed |
| US-6958080-B2 | Compositions for dyeing keratinous fiber | LION CORPORATION (JP) | 2005-10-25 | — | — | US | disclosed |
| EP-1234569-A1 | COMPOSITIONS FOR DYEING HORNY FIBERS | Lion Corporation (JP) | 2002-08-28 | — | — | EP | disclosed |