Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4626549 | 0.89 | TSHR (0.73) | ALDH1A1SLC6A4SLC6A3SIGMAR1TSHR | |
| SCHEMBL2056136 | 0.86 | ALDH1A1 (1.00) | ALDH1A1SLC6A4SLC6A3TSHRMEN1 | |
| SCHEMBL5450666 | 0.83 | SLC6A4 (0.54) | ALDH1A1SLC6A4SLC6A3SIGMAR1TSHR | |
| SCHEMBL2092331 | 0.83 | SLC6A4 (0.58) | ALDH1A1SLC6A4SLC6A3SIGMAR1TSHR | |
| SCHEMBL2056182 | 0.81 | ALDH1A1 (0.89) | ALDH1A1SLC6A4SLC6A3TSHRHRH3 | |
| SCHEMBL4704073 | 0.81 | SPHK1 (0.55) | ALDH1A1SLC6A4SLC6A3SIGMAR1TSHR | |
| SCHEMBL2157301 | 0.80 | LTA4H (0.55) | ALDH1A1SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL2158179 | 0.80 | KCNH2 (0.64) | HRH3ACHE | |
| SCHEMBL5540044 | 0.79 | ALDH1A1 (0.49) | ALDH1A1SLC6A4SLC6A3SIGMAR1TSHR | |
| SCHEMBL5540053 | 0.79 | ALDH1A1 (0.50) | ALDH1A1SLC6A4SLC6A3SIGMAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687288-B1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH CORP (US) | 2008-01-16 | — | — | EP | claimed |
| EP-1957473-A2 | PROCESS FOR PREPARING SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2008-08-20 | — | — | EP | disclosed |
| US-7365076-B2 | Substituted aryl cycloalkanol derivatives and methods of their use | WYETH (US) | 2008-04-29 | — | — | US | disclosed |
| EP-1687288-B1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2007067575-A2 | PROCESS FOR PREPARING SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES | WYETH (US) | 2007-06-14 | — | — | WO | disclosed |
| US-20050143579-A1 | Substituted aryl cycloalkanol derivatives and methods of their use | WYETH (US) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143579-A1 | Substituted aryl cycloalkanol derivatives and methods of their use | HTR3A, MAOA, FAAH | ALDH1A1 445/4885SLC6A4 72/4885SLC6A3 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.