Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4627931 | 0.99 | GRIN1 (0.55) | GRIN1GRIN2BHDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL7041561 | 0.99 | GRIN1 (0.55) | GRIN1GRIN2BHDAC3HDAC1HDAC2 | |
| SCHEMBL4625918 | 0.92 | KDM4E (0.55) | GRIN1GRIN2BHDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL4626360 | 0.91 | KDM4E (0.54) | GRIN1GRIN2BHDAC3HDAC1HDAC2 | |
| SCHEMBL4626265 | 0.85 | RAB9A (0.56) | HDAC3HDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL4625281 | 0.85 | LMNA (0.55) | HDAC3HDAC1HDAC2HDAC8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4626728 | 0.84 | LMNA (0.54) | HDAC3HDAC1HDAC2HDAC8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4627120 | 0.84 | RAB9A (0.58) | HDAC3HDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL4625875 | 0.84 | MMP1 (0.50) | HDAC4MEF2DALDH1A1MMP13MMP1 | |
| Hydrochloric Acid SCHEMBL4626151 | 0.83 | MMP1 (0.49) | HDAC4MEF2DALDH1A1MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296940-B1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME (GB) | 2008-07-02 | — | — | EP | claimed |
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | CURTIS NEIL ROY (GB) | 2003-06-26 | — | — | US | claimed |
| EP-1296940-A1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2003-04-02 | — | — | EP | claimed |
| WO-2001098262-A1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-12-27 | — | — | WO | claimed |
| EP-1296940-B1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME (GB) | 2008-07-02 | — | — | EP | disclosed |
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | CURTIS NEIL ROY (GB) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | GRIN1, GRIN2A, GRM1 | GRIN1 1/4885GRIN2B 6/4885HDAC3 432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.