Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | FOS | P01100 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4626360 | 0.99 | KDM4E (0.54) | KDM4EALDH1A1HTTBCHEPOLB | |
| SCHEMBL4626376 | 0.92 | GRIN1 (0.56) | KDM4EALDH1A1HTTPOLBPKM | |
| Hydrochloric Acid SCHEMBL4627931 | 0.91 | GRIN1 (0.55) | KDM4EALDH1A1HTTPOLBPKM | |
| Hydrochloric Acid SCHEMBL7041561 | 0.91 | GRIN1 (0.55) | KDM4EALDH1A1HTTPOLBPKM | |
| SCHEMBL4625281 | 0.85 | LMNA (0.55) | ALDH1A1BCHEMAOBMEN1KMT2A | |
| SCHEMBL4626265 | 0.85 | RAB9A (0.56) | KDM4EALDH1A1PKMMMP1MMP2 | |
| SCHEMBL28891777 | 0.85 | ALDH1A1 (0.73) | KDM4EALDH1A1HTTBCHEPKM | |
| Hydrochloric Acid SCHEMBL4627120 | 0.84 | RAB9A (0.58) | KDM4EALDH1A1PKMMMP1MMP2 | |
| Hydrochloric Acid SCHEMBL4626728 | 0.84 | LMNA (0.54) | ALDH1A1BCHEMAOBMEN1KMT2A | |
| SCHEMBL5082489 | 0.82 | MMP1 (0.65) | ALDH1A1BCHEPOLBMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296940-B1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME (GB) | 2008-07-02 | — | — | EP | claimed |
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | CURTIS NEIL ROY (GB) | 2003-06-26 | — | — | US | claimed |
| EP-1296940-B1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME (GB) | 2008-07-02 | — | — | EP | disclosed |
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | CURTIS NEIL ROY (GB) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | GRIN1, GRIN2A, GRM1 | KDM4E 3585/4885ALDH1A1 4432/4885HTT 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.