Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.55 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.55 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.55 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4626728 | 0.99 | LMNA (0.54) | LMNAALDH1A1MEN1KMT2APLAAT3 | |
| SCHEMBL4626265 | 0.94 | RAB9A (0.56) | LMNAALDH1A1MEN1KMT2APLAAT3 | |
| Hydrochloric Acid SCHEMBL4627120 | 0.93 | RAB9A (0.58) | LMNAALDH1A1MEN1KMT2APLAAT3 | |
| SCHEMBL4626376 | 0.85 | GRIN1 (0.56) | LMNAALDH1A1MAOBHDAC3HDAC1 | |
| SCHEMBL4625918 | 0.85 | KDM4E (0.55) | LMNAALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL5082489 | 0.85 | MMP1 (0.65) | LMNAALDH1A1MEN1KMT2APLAAT3 | |
| SCHEMBL3029548 | 0.85 | MMP1 (0.65) | LMNAALDH1A1MEN1KMT2APLAAT3 | |
| Hydrochloric Acid SCHEMBL4626360 | 0.84 | KDM4E (0.54) | LMNAALDH1A1MEN1KMT2AMAOB | |
| Hydrochloric Acid SCHEMBL7041561 | 0.84 | GRIN1 (0.55) | LMNAALDH1A1MAOBHDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL4627931 | 0.84 | GRIN1 (0.55) | LMNAALDH1A1MAOBHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296940-B1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME (GB) | 2008-07-02 | — | — | EP | claimed |
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | CURTIS NEIL ROY (GB) | 2003-06-26 | — | — | US | claimed |
| EP-1296940-B1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME (GB) | 2008-07-02 | — | — | EP | disclosed |
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | CURTIS NEIL ROY (GB) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119871-A1 | Amidine derivatives as selective antagonists of ndma receptors | GRIN1, GRIN2A, GRM1 | LMNA 1855/4885ALDH1A1 4432/4885MEN1 3385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.