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Glutamic Acid

Glutamic Acid

SCHEMBL4628258

CC(CC(NC(=O)c1ccc(NCC2CNc3nc(N)[nH]c(=O)c3N2)cc1)C(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O

nearest known ligand 0.80

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Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SOST Q9BQB4 1/20 0.80
▸ FPGS Q05932 2/20 0.72
▸ GART P22102 5/20 0.61
▸ DHFR P00374 1/20 0.55
▸ ATIC P31939 4/20 0.53
▸ MTHFD1 P11586 2/20 0.53
▸ MTHFD2 P13995 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Homocysteine SCHEMBL27706413 0.93 SOST (0.70) SOSTFPGSGARTDHFRATIC
L-Homocysteine SCHEMBL1888976 0.93 SOST (0.70) SOSTFPGSGARTDHFRATIC
Tetrahydrofolate SCHEMBL4628326 0.93 SOST (0.92) SOSTFPGSGARTDHFRATIC
Tetrahydrofolate SCHEMBL23630632 0.93 SOST (0.92) SOSTFPGSGARTDHFRATIC
Tetrahydrofolate SCHEMBL21248573 0.93 SOST (0.92) SOSTFPGSGARTDHFRATIC
SCHEMBL15121249 0.93 SOST (0.78) SOSTFPGSGARTDHFRATIC
SCHEMBL3953439 0.93 SOST (0.78) SOSTFPGSGARTDHFRATIC
SCHEMBL50298 0.93 SOST (0.78) SOSTFPGSGARTDHFRATIC
SCHEMBL716106 0.93 SOST (0.78) SOSTFPGSGARTDHFRATIC
SCHEMBL28469783 0.92 SOST (0.77) SOSTFPGSGARTDHFRATIC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1917006-A2 USE OF INHIBITORS OF N-METHYL TRANSFERASES FOR THE THERAPY OF PARKINSON'S DISEASE PLT Patent & Licence Trading Ltd. (GB) 2008-05-07 — — EP claimed
WO-2006136454-A2 USE OF INHIBITORS OF N-METHYL TRANSFERASES FOR THE THERAPY OF PARKINSON'S DISEASE PLT PATENT & LICENCE TRADING LTD. (GB) 2006-12-28 — — WO claimed