Pyridazine

Pyridazine

SCHEMBL462827

c1cc2cc-2c1.c1ccnnc1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.43
ESR1 P03372 1/20 0.43
KMT2A Q03164 1/20 0.43
APP P05067 1/20 0.42
NISCH Q9Y2I1 1/20 0.39
CYP3A4 P08684 3/20 0.39
CYP2C9 P11712 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2A6 P11509 2/20 0.39
CYP1A1 P04798 1/20 0.39
CYP2E1 P05181 1/20 0.39
CYP2C8 P10632 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP4B1 P13584 1/20 0.39
CYP2B6 P20813 1/20 0.39
CYP3A5 P20815 1/20 0.39
CYP2A7 P20853 1/20 0.39
CYP3A7 P24462 1/20 0.39
CYP2F1 P24903 1/20 0.39
CYP2C18 P33260 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4969576 0.79
SCHEMBL28449767 0.78 NISCH (0.47) MEN1ESR1KMT2ANISCHMAOA
Biphenyl SCHEMBL27478909 0.78 ALDH1A1 (0.60) MEN1KMT2ANISCHCYP3A4CYP1A2
Pyridazine SCHEMBL663154 0.76 LMNA (0.41) MEN1ESR1KMT2ANISCHCYP3A4
Methyl Alcohol SCHEMBL27613845 0.76
Methane SCHEMBL17800724 0.75
Ammonia Solution, Strong SCHEMBL2325144 0.75
Benzene SCHEMBL475971 0.75 MEN1 (0.56) MEN1ESR1KMT2AAPPCYP3A4
Hydrogen Sulfide SCHEMBL3569701 0.75
SCHEMBL31290738 0.75 MEN1 (0.65) MEN1ESR1KMT2AAPPCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180263961-A1 SELENIUM CONTAINING KGA/GDH DUAL INHIBITORS AND THE APPLICATIONS THEREOF HANGZHOU GAMMA BIOTECH CO., LTD. (CN) 2018-09-20 US claimed
US-20120234750-A1 THERMALLY, HEAT AND CHEMICALLY RESISTANT ULTRAFILTRATION POLYIMIDE MEMBRANE AND METHOD FOR ITS PRODUCTION POLOTSKAYA GALINA A (US) 2012-09-20 US claimed
US-20120217444-A1 COMPOSITION AND METHOD FOR INHIBITING PREMATURE POLYMERIZATION GENERAL ELECTRIC COMPANY 2012-08-30 US claimed
US-8210361-B2 Thermally, heat and chemically resistant ultrafiltration polyimide membrane and method for its production POLOTSKAYA GALINA A (RU) 2012-07-03 US claimed
WO-2012033800-A1 COMPOSITION AND METHOD FOR INHIBITING PREMATURE POLYMERIZATION GENERAL ELECTRIC COMPANY (US) 2012-03-15 WO claimed
US-20040019134-A1 Flame retarded epoxy resin composition CHANG CHUN PLASTICS CO., LTD. 2004-01-29 US claimed
US-6660786-B2 Flame retarded epoxy resin composition CHANG CHUN PLASTICS, CO., LTD. (TW) 2003-12-09 US claimed
US-20020082322-A1 Flame retarded epoxy resin composition CHANG CHUN PLASTICS, CO., LTD. (TW) 2002-06-27 US claimed
US-4983288-A Filter element with membrane-type filter material SEITZ-FILTER-WERKE THEO & GEO SEITZ GMBH UND CO. (DE) 1991-01-08 US claimed
US-4021368-A Process of treating mycelia of fungi for retention of metals CESKOSLOVENSKA KOMISE PRO ATOMOVOU ENERGII PRAHA (CS) 1977-05-03 US claimed
JP-4244222-A None JP disclosed
JP-61195130-A None JP disclosed
EP-3524338-B1 PROCESS OF WATER EXTRACTION AQUAPORIN AS (DK) 2024-06-19 EP disclosed
US-20240017217-A1 SPACERS COMPATIBLE WITH ACTIVE LAYER IN FLUID FILTRATION ELEMENTS SQN VENTURE INCOME FUND III, LP 2024-01-18 US disclosed
US-11813579-B2 Systems for water extraction for up-concentration of organic solutes AQUAPORIN A/S (DK) 2023-11-14 US disclosed
US-4277390-A PROTECTIVE COATINGS AND SEALS KULIEV ALADDIN M O 1981-07-07 US disclosed
US-4172937-A REACTION OF A DIALDEHYDE AND DIAMINE IN A PHENOLIC COMPOUND ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1979-10-30 US disclosed
US-3956322-A Dianhydrides of bis-(orthodicarboxyphenyloxyphenyl)acetylene and bis-(ortho-dicarboxyphenyloxyphenyl)2,2-dichloroethylene GENERAL ELECTRIC COMPANY (US) 1976-05-11 US disclosed
US-3944583-A Bis-phenoxyphthalic acid anhydrides GENERAL ELECTRIC COMPANY (US) 1976-03-16 US disclosed
US-3932122-A COLORING POLYESTER TEXTILES CIBA-GEIGY AG (CH) 1976-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180263961-A1 SELENIUM CONTAINING KGA/GDH DUAL INHIBITORS AND THE APPLICATIONS THEREOF OGDH, GLS, GCDH MEN1 3477/4885ESR1 3342/4885KMT2A 179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.