Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 9/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628396 | 0.87 | FYN (0.47) | FYNCRHR1CCNA2CDK2CCNA1 | |
| SCHEMBL21140560 | 0.77 | FYN (0.38) | FYNCRHR1CCNA2CDK2CCNA1 | |
| SCHEMBL5416416 | 0.72 | FYN (0.44) | FYNCRHR1CCNA2CDK2CCNA1 | |
| SCHEMBL4628001 | 0.71 | FYN (0.46) | FYNCRHR1CCNA2CDK2CCNA1 | |
| SCHEMBL15357781 | 0.70 | TRPM8 (0.41) | DYRK1AHCAR3 | |
| SCHEMBL6469022 | 0.70 | HCAR3 (0.38) | FYNCRHR1ADRA1ACCNA2CDK2 | |
| SCHEMBL6468910 | 0.68 | FYN (0.51) | FYNCRHR1CCNA2CDK2CCNA1 | |
| SCHEMBL5414326 | 0.68 | FYN (0.46) | FYNCRHR1CCNA2CDK2CCNA1 | |
| SCHEMBL14544920 | 0.67 | CRHR1 (0.48) | FYNCRHR1TAS1R3TAS1R1SYK | |
| SCHEMBL15864503 | 0.67 | FYN (0.58) | FYNCRHR1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008083070-A1 | CRF1 RECEPTOR LIGANDS COMPRISING FUSED BICYCLIC HETEROARYL MOIETIES | NEUROGEN CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |