Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698684 | 0.77 | KMT2A (0.40) | KMT2AMEN1L3MBTL1TDP1RAB9A | |
| SCHEMBL7700237 | 0.76 | GAA (0.44) | KMT2AMEN1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6324391 | 0.75 | GAA (0.43) | KMT2AMEN1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL480202 | 0.74 | GAA (0.42) | KMT2AMEN1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5406500 | 0.73 | GAA (0.52) | KMT2AMEN1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL30677857 | 0.73 | KMT2A (0.43) | KMT2AMEN1L3MBTL1TDP1RAB9A | |
| SCHEMBL2968082 | 0.73 | SMN1; SMN2 (0.53) | KMT2AMEN1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL84806 | 0.73 | L3MBTL1 (0.73) | KMT2AMEN1L3MBTL1TDP1SMN1; SMN2 | |
| SCHEMBL3839653 | 0.73 | L3MBTL1 (0.73) | KMT2AMEN1L3MBTL1TDP1SMN1; SMN2 | |
| SCHEMBL493880 | 0.72 | TP53 (0.50) | KMT2AMEN1L3MBTL1TDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |