Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700237 | 0.98 | GAA (0.44) | GAAHTTSMN1; SMN2RAB9ATP53 | |
| SCHEMBL6324391 | 0.80 | GAA (0.43) | GAAHTTSMN1; SMN2RAB9ATP53 | |
| SCHEMBL5406500 | 0.78 | GAA (0.52) | GAAHTTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7698684 | 0.77 | KMT2A (0.40) | GAAHTTSMN1; SMN2RAB9ATP53 | |
| SCHEMBL4630170 | 0.74 | KMT2A (0.47) | GAAHTTSMN1; SMN2RAB9ATP53 | |
| SCHEMBL1882976 | 0.73 | GAA (0.48) | GAAHTTSMN1; SMN2RAB9AHPGD | |
| SCHEMBL9184806 | 0.73 | GAA (0.48) | GAAHTTSMN1; SMN2RAB9AHPGD | |
| SCHEMBL47336 | 0.73 | KMT2A (0.48) | HTTKMT2AATMALDH1A1POLB | |
| SCHEMBL10475080 | 0.72 | ALDH1A1 (0.45) | GAAHTTSMN1; SMN2RAB9ATP53 | |
| SCHEMBL23152448 | 0.72 | GAA (0.52) | GAAHTTSMN1; SMN2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143427-B2 | Method for producing aminoacetylpyrrolidinecarbonitrile derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-03-27 | — | — | US | claimed |
| EP-2123636-B1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN SEIYAKU KK (JP) | 2012-03-21 | — | — | EP | claimed |
| US-20120029032-A1 | MATRIX-TYPE SUSTAINED RELEASE PREPARATION CONTAINING BASIC ADDITIVE | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-02-02 | — | — | US | claimed |
| EP-2412370-A1 | MATRIX-TYPE SUSTAINED RELEASE PREPARATION CONTAINING BASIC ADDITIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2012-02-01 | — | — | EP | claimed |
| US-20100099892-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN PHARMACEUTICAL CO. LTD | 2010-04-22 | — | — | US | claimed |
| EP-2123636-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2009-11-25 | — | — | EP | claimed |
| US-8143427-B2 | Method for producing aminoacetylpyrrolidinecarbonitrile derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-03-27 | — | — | US | disclosed |
| US-8143427-B2 | Method for producing aminoacetylpyrrolidinecarbonitrile derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-03-27 | — | — | US | disclosed |
| EP-2123636-B1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN SEIYAKU KK (JP) | 2012-03-21 | — | — | EP | disclosed |
| EP-2123636-B1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN SEIYAKU KK (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-20120029032-A1 | MATRIX-TYPE SUSTAINED RELEASE PREPARATION CONTAINING BASIC ADDITIVE | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-02-02 | — | — | US | disclosed |
| EP-2412370-A1 | MATRIX-TYPE SUSTAINED RELEASE PREPARATION CONTAINING BASIC ADDITIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2012-02-01 | — | — | EP | disclosed |
| US-7915427-B2 | Process for producing aminoacetyl pyrrolidine carbonitrile derivative and intermediate for production thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2011-03-29 | — | — | US | disclosed |
| JP-2010070454-A | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND PRODUCTION INTERMEDIATE OF THE SAME | KYORIN PHARMACEUT CO LTD | 2010-04-02 | — | — | JP | disclosed |
| EP-2123636-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2009-11-25 | — | — | EP | disclosed |
| EP-2123636-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2009-11-25 | — | — | EP | disclosed |
| JP-2009114127-A | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN PHARMACEUT CO LTD | 2009-05-28 | — | — | JP | disclosed |
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | KYORIN PHARMACEUTICALS CO., LTD. (JP) | 2009-02-19 | — | — | US | disclosed |
| EP-1995237-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE AND PRODUCTION INTERMEDIATE THEREOF | Kyorin Pharmaceutical Co., Ltd. (JP) | 2008-11-26 | — | — | EP | disclosed |
| WO-2008114857-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099892-A1 | METHOD FOR PRODUCING AMINOACETYLPYRROLIDINECARBONITRILE DERIVATIVE | DPP4, DPP7, DPP8 | GAA 1799/4885HTT 3515/4885SMN1; SMN2 4352/4885 |
| US-20090048454-A1 | Process for Producing Aminoacetyl Pyrrolidine Carbonitrile Derivative and Intermediate for Production Thereof | CBR3, CPS1, CBR1 | GAA 3647/4885HTT 1675/4885SMN1; SMN2 3794/4885 |
| US-20120029032-A1 | MATRIX-TYPE SUSTAINED RELEASE PREPARATION CONTAINING BASIC ADDITIVE | MMP7, COL2A1, MMP17 | GAA 79/4885HTT 3209/4885SMN1; SMN2 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.