Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | LSS | P48449 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384185 | 0.70 | PKM (0.46) | HPGDKDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL4630809 | 0.70 | DRD2 (0.33) | — | |
| SCHEMBL15197111 | 0.63 | HPGD (0.55) | HPGDKDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL19584786 | 0.62 | PTGDR2 (0.49) | ALDH1A1MAPK1HSD17B10NPC1PTGDR2 | |
| SCHEMBL13254946 | 0.61 | KDM4E (0.38) | HPGDKDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL31085238 | 0.60 | LMNA (0.35) | HPGDKDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL12805307 | 0.60 | MRGPRX4 (0.53) | ALDH1A1PTGDR2 | |
| SCHEMBL25842210 | 0.60 | NOTUM (0.53) | MEN1KMT2A | |
| SCHEMBL31085211 | 0.59 | ALDH1A1 (0.36) | HPGDKDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL2955119 | 0.59 | KMT2A (0.62) | HPGDKDM4EALDH1A1HSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470103-B1 | AMIDOACETONITRILE DERIVATIVES | NOVARTIS AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| US-7153814-B2 | Amidoacetonitrile derivatives | NOVARTIS ANIMAL HEALTH US, INC. (US) | 2006-12-26 | — | — | US | disclosed |
| US-20050059736-A1 | Amidoacetonitrile derivatives | NOVARTIS ANIMAL HEALTH US, INC. | 2005-03-17 | — | — | US | disclosed |
| EP-1470103-A1 | AMIDOACETONITRILE DERIVATIVES | Novartis AG (CH) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003059868-A1 | AMIDOACETONITRILE DERIVATIVES | NOVARTIS AG (CH) | 2003-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059736-A1 | Amidoacetonitrile derivatives | ARG1, NAT1, NMBR | HPGD 2487/4885KDM4E 4454/4885ALDH1A1 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.