Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30003208 | 0.80 | L3MBTL1 (0.48) | NPSR1L3MBTL1ALDH1A1LMNAPOLB | |
| SCHEMBL17048125 | 0.77 | KMT2A (0.47) | ROCK2LMNAPOLBHTTKMT2A | |
| SCHEMBL20353615 | 0.76 | ROCK2 (0.42) | ROCK2KDM4EMAPTGAAHPGD | |
| SCHEMBL28413236 | 0.75 | APP (0.42) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL4519070 | 0.74 | ROCK2 (0.52) | ROCK2NPSR1ALDH1A1KDM4EMAPT | |
| SCHEMBL26191686 | 0.73 | ALDH1A1 (0.43) | ROCK2HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL10175794 | 0.72 | ROCK2 (0.46) | ROCK2KDM4EMAPTGAAHPGD | |
| SCHEMBL29525834 | 0.72 | ROCK2 (0.46) | ROCK2KDM4EMAPTGAAHPGD | |
| SCHEMBL13450008 | 0.72 | HRH2 (0.49) | ROCK2ALDH1A1POLBHTTGAA | |
| SCHEMBL4630869 | 0.72 | MEN1 (0.62) | HTR2AHTR2CHTR2BL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470103-B1 | AMIDOACETONITRILE DERIVATIVES | NOVARTIS AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| US-7153814-B2 | Amidoacetonitrile derivatives | NOVARTIS ANIMAL HEALTH US, INC. (US) | 2006-12-26 | — | — | US | disclosed |
| US-20050059736-A1 | Amidoacetonitrile derivatives | NOVARTIS ANIMAL HEALTH US, INC. | 2005-03-17 | — | — | US | disclosed |
| EP-1470103-A1 | AMIDOACETONITRILE DERIVATIVES | Novartis AG (CH) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003059868-A1 | AMIDOACETONITRILE DERIVATIVES | NOVARTIS AG (CH) | 2003-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059736-A1 | Amidoacetonitrile derivatives | ARG1, NAT1, NMBR | ROCK2 2761/4885HTR2A 3415/4885HTR2C 3880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.