Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015092 | 0.79 | NSD2 (0.63) | CYP2A6NSD2POLBLOXL2PYCR1 | |
| SCHEMBL12749574 | 0.78 | PYCR1 (0.52) | CYP2A6PYCR1IDO1HRH3 | |
| SCHEMBL23374744 | 0.78 | CYP2A6 (0.57) | CYP2A6NSD2POLBLOXL2SIGMAR1 | |
| SCHEMBL4632355 | 0.77 | PYCR1 (0.41) | LOXL2PYCR1MAOBHRH3 | |
| SCHEMBL21962259 | 0.77 | PYCR1 (0.53) | PYCR1MAOBLSS | |
| SCHEMBL1472497 | 0.77 | NR1I2 (0.42) | PYCR1MAOBKIF11HRH3 | |
| SCHEMBL7039840 | 0.77 | SIGMAR1 (0.57) | CYP2A6PYCR1SIGMAR1TMEM97CRHBP | |
| SCHEMBL1009445 | 0.77 | PYCR1 (0.38) | PYCR1SIGMAR1MAOBHRH3 | |
| SCHEMBL23032284 | 0.76 | ALDH1A1 (0.52) | PYCR1SIGMAR1MAOB | |
| SCHEMBL156261 | 0.75 | CYP2A6 (0.58) | CYP2A6NSD2POLBLOXL2CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924561-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | Eli Lilly & Company (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007028083-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |