Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631768 | 0.83 | CDK2 (0.52) | CDK2CDK1CDK4CCNA2CCNA1 | |
| SCHEMBL4633594 | 0.82 | FGFR1 (0.48) | CDK2CDK1CCNA2CCNA1AURKA | |
| SCHEMBL4633224 | 0.78 | CA1 (0.46) | MAPK1 | |
| SCHEMBL4632550 | 0.77 | RAB9A (0.46) | — | |
| SCHEMBL4632682 | 0.76 | HDAC6 (0.38) | — | |
| SCHEMBL4633621 | 0.76 | MAPK1 (0.46) | MAPK1 | |
| SCHEMBL4632643 | 0.76 | ADORA3 (0.47) | CDK2MAPK1GSK3B | |
| SCHEMBL2412951 | 0.76 | CDK2 (0.45) | CDK2CDK1CDK4CCNA2CCNA1 | |
| SCHEMBL2415683 | 0.76 | CDK2 (0.46) | CDK2CDK1CDK4MAPK1MAPK14 | |
| SCHEMBL2417194 | 0.76 | MAPT (0.48) | CDK2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |