Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 6/20 | 0.41 |
| ▸ | KIT | P10721 | 5/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633601 | 0.91 | FLT3 (0.42) | HDAC6HDAC1HDAC8FLT3KIT | |
| SCHEMBL4632670 | 0.89 | FLT3 (0.51) | HDAC6HDAC1FLT3KITFGFR1 | |
| SCHEMBL2432182 | 0.87 | AURKA (0.41) | HDAC6HDAC1HDAC8FLT3KIT | |
| SCHEMBL3093101 | 0.86 | HDAC6 (0.46) | HDAC6HDAC1HDAC8FLT3KIT | |
| SCHEMBL4632682 | 0.84 | HDAC6 (0.38) | HDAC6HDAC1FLT3KITFGFR1 | |
| SCHEMBL4631888 | 0.82 | NPC1 (0.42) | HDAC6FGFR1FGFR2FGFR3 | |
| SCHEMBL4632536 | 0.82 | FLT3 (0.51) | HDAC6FLT3KITNTRK1FGFR1 | |
| SCHEMBL4633594 | 0.81 | FGFR1 (0.48) | HDAC6FLT3AURKAFGFR1FGFR2 | |
| SCHEMBL4632622 | 0.81 | HDAC6 (0.53) | HDAC6FLT3AURKA | |
| SCHEMBL4632650 | 0.80 | HDAC6 (0.42) | HDAC6FLT3NTRK1FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |