Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | PRKX | P51817 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633207 | 0.91 | HDAC6 (0.45) | FLT3KITHDAC6FGFR1HDAC1 | |
| SCHEMBL4632670 | 0.90 | FLT3 (0.51) | FLT3KITHDAC6FGFR1LRRK2 | |
| SCHEMBL3090928 | 0.87 | FLT3 (0.42) | FLT3KITHDAC6LRRK2CDC7 | |
| SCHEMBL4632536 | 0.83 | FLT3 (0.51) | FLT3KITHDAC6FGFR1CDC7 | |
| SCHEMBL4632682 | 0.83 | HDAC6 (0.38) | FLT3KITHDAC6FGFR1CDK7 | |
| SCHEMBL4631888 | 0.81 | NPC1 (0.42) | HDAC6FGFR1LRRK2RXFP1MEN1 | |
| SCHEMBL4633594 | 0.80 | FGFR1 (0.48) | FLT3HDAC6FGFR1MAP4K4CDK2 | |
| SCHEMBL4632622 | 0.80 | HDAC6 (0.53) | FLT3HDAC6CDK2CDK7TP53 | |
| SCHEMBL2432182 | 0.80 | AURKA (0.41) | FLT3KITHDAC6FGFR1HDAC1 | |
| SCHEMBL4632650 | 0.80 | HDAC6 (0.42) | FLT3HDAC6FGFR1CDC7DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |