Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.42 |
| ▸ | MMP9 | P14780 | 4/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069723 | 0.94 | ALOX5 (0.45) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL4736749 | 0.93 | TACR1 (0.46) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL4736756 | 0.93 | MMP9 (0.49) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL13945806 | 0.93 | MMP9 (0.47) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL4735529 | 0.92 | MEN1 (0.47) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL4735787 | 0.92 | KMT2A (0.45) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL4633412 | 0.92 | GPR84 (0.45) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL4735841 | 0.92 | MEN1 (0.41) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL4041218 | 0.91 | CTSL (0.44) | MEN1KMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL4634227 | 0.91 | TACR1 (0.44) | MEN1KMT2AHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221195-A1 | 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS | BAYER SCHERING PHARMA AG (DE) | 2008-09-11 | — | — | US | claimed |
| EP-1932831-A1 | 1,2-Diarylacetylene Derivatives of Acyltryptophanols | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-06-18 | — | — | EP | claimed |
| US-20080221195-A1 | 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS | BAYER SCHERING PHARMA AG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080221195-A1 | 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS | BAYER SCHERING PHARMA AG (DE) | 2008-09-11 | — | — | US | disclosed |
| WO-2008071453-A1 | 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | disclosed |
| EP-1932831-A1 | 1,2-Diarylacetylene Derivatives of Acyltryptophanols | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-06-18 | — | — | EP | disclosed |
| EP-1932831-A1 | 1,2-Diarylacetylene Derivatives of Acyltryptophanols | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221195-A1 | 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS | FSHR, GNRHR, TPH1 | MEN1 188/4885KMT2A 715/4885HDAC3 1526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.