SCHEMBL4633992

SCHEMBL4633992

C=CCc1nc2cccc(N)c2[nH]1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.34
KDR P35968 1/20 0.34
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
MAPT P10636 5/20 0.33
KDM4E B2RXH2 4/20 0.33
HSD17B10 Q99714 3/20 0.33
HIF1A Q16665 1/20 0.33
HPGD P15428 5/20 0.32
ALDH1A1 P00352 4/20 0.32
HTT P42858 1/20 0.32
IMPDH2 P12268 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
NPC1 O15118 2/20 0.32
GLA P06280 2/20 0.32
GAA P10253 2/20 0.32
RAB9A P51151 2/20 0.32
NPSR1 Q6W5P4 2/20 0.32
TP53 P04637 1/20 0.32
POLB P06746 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2163313 0.82 MAPT (0.40) KMT2AMEN1MAPTHIF1AHPGD
SCHEMBL28154129 0.81 LMNA (0.36) KMT2AMEN1MAPTKDM4EHPGD
SCHEMBL3258411 0.81 ALDH1A1 (0.39) KMT2AMEN1MAPTKDM4EHPGD
SCHEMBL10634839 0.81 ACHE (0.36) KMT2AMEN1MAPTKDM4EHSD17B10
SCHEMBL8921610 0.80 POLB (0.42) KMT2AMEN1MAPTKDM4EHPGD
SCHEMBL5736942 0.80 RET (0.37) RETKDRKMT2AMEN1MAPT
SCHEMBL3938947 0.78 TDP1 (0.40) RETKDRKMT2AMEN1MAPT
SCHEMBL9228130 0.77 ALDH1A1 (0.39) KMT2AMEN1MAPTKDM4EHSD17B10
SCHEMBL5182915 0.77 ADORA3 (0.37) KDRKMT2AMEN1MAPTKDM4E
SCHEMBL7564206 0.75 GAA (0.44) KMT2AMAPTKDM4EHSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2468530-B1 Pneumatic tyres for a vehicle CONTINENTAL REIFEN DEUTSCHLAND (DE) 2014-02-26 EP claimed
WO-2012084345-A1 PNEUMATIC TIRE FOR VEHICLES CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2012-06-28 WO claimed
EP-2468530-A1 Pneumatic tyres for a vehicle Continental Reifen Deutschland GmbH (DE) 2012-06-27 EP claimed
EP-1657320-A1 Fluid and its use to prepare iron and steel based mixtures Zschimmer & Schwarz GmbH & Co KG Chemische Fabriken (DE) 2006-05-17 EP claimed
US-20060090592-A1 Liquid, its use for the preparation of powder mixtures on the basis of iron or stainless steel as well as a method for the preparation of powder mixtures on the basis of iron or stainless steel ZSCHIMMER & SCHWARZ GMBH & CO. KG CHEMISCHE FABRIKEN 2006-05-04 US claimed
WO-1992022686-A1 METHOD OF PRETREATING THE SURFACES OF NON-FERROUS METALS PRIOR TO GALVANIC DEPOSITION OF A COAT OF METAL HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1992-12-23 WO claimed
WO-2015161842-A1 AFTER-CLEANING METHOD FOR METALLIC CONTACT ELEMENTS HARTING KGAA (DE) 2015-10-29 WO disclosed
EP-2468530-B1 Pneumatic tyres for a vehicle CONTINENTAL REIFEN DEUTSCHLAND (DE) 2014-02-26 EP disclosed
WO-2012084345-A1 PNEUMATIC TIRE FOR VEHICLES CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2012-06-28 WO disclosed
EP-2468530-A1 Pneumatic tyres for a vehicle Continental Reifen Deutschland GmbH (DE) 2012-06-27 EP disclosed
EP-1657320-B1 Use of a fluid to prepare iron and steel based mixtures ZSCHIMMER & SCHWARZ GMBH & CO (DE) 2008-02-27 EP disclosed
EP-1657320-A1 Fluid and its use to prepare iron and steel based mixtures Zschimmer & Schwarz GmbH & Co KG Chemische Fabriken (DE) 2006-05-17 EP disclosed