Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163313 | 0.82 | MAPT (0.40) | LMNASMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL10634839 | 0.81 | ACHE (0.36) | LMNARAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL3258411 | 0.81 | ALDH1A1 (0.39) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL4633992 | 0.81 | RET (0.34) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5738320 | 0.78 | LMNA (0.39) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1918625 | 0.78 | DDAH1 (0.53) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL25369555 | 0.78 | TDP1 (0.47) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL31345698 | 0.78 | TDP1 (0.47) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7252462 | 0.78 | LMNA (0.39) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9228130 | 0.77 | ALDH1A1 (0.39) | RAB9AKDM4EMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106699670-B | Benzimidazolyl piperazine compounds and its preparation method and pharmaceutical composition | 沈阳海王生物技术有限公司 | 2019-11-19 | — | — | CN | disclosed |
| CN-103833643-B | Benzimidazolyl piperazine compound and preparation method and pharmaceutical composition thereof | 沈阳海王生物技术有限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-106699670-A | Benzimidazolyl piperazine compounds, preparation method thereof and pharmaceutical composition | 辽宁艾美生物医药产业有限公司 | 2017-05-24 | — | — | CN | disclosed |