SCHEMBL4635501

SCHEMBL4635501

O=C(O)c1ccc(NC(=O)c2ccc(F)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MITF O75030 1/20 1.00
RAB9A P51151 4/20 0.76
NPC1 O15118 3/20 0.76
PTPN1 P18031 1/20 0.76
MEN1 O00255 5/20 0.72
KMT2A Q03164 5/20 0.72
POLB P06746 2/20 0.72
TDP1 Q9NUW8 1/20 0.72
ATM Q13315 1/20 0.67
P4HTM Q9NXG6 2/20 0.66
FFAR1 O14842 1/20 0.66
SNCA P37840 1/20 0.65
KCNK3 O14649 1/20 0.62
KCNK9 Q9NPC2 1/20 0.62
HTT P42858 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3639776 1.00 MITF (1.00) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL10684470 0.92 PTPN1 (0.88) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL8827340 0.90 MITF (0.81) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL900903 0.90 MITF (0.81) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL28419632 0.90 MITF (0.81) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL8768807 0.86 MEN1 (0.86) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL8770854 0.86 PTPN1 (0.79) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL2567644 0.86 RAB9A (1.00) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL4922979 0.86 MITF (0.76) MITFRAB9ANPC1PTPN1MEN1
SCHEMBL4783063 0.86 MEN1 (0.86) MITFRAB9ANPC1PTPN1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3049387-B1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & CO (US) 2020-11-11 EP disclosed
EP-3049387-B1 THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & CO (US) 2020-11-11 EP disclosed
EP-3049388-B1 NUCLEATING AGENT FOR THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & CO (US) 2019-08-07 EP disclosed
EP-3049388-B1 NUCLEATING AGENT FOR THERMOPLASTIC POLYMER COMPOSITION MILLIKEN & CO (US) 2019-08-07 EP disclosed
EP-3049388-A1 THERMOPLASTIC POLYMER COMPOSITION Milliken & Company (US) 2016-08-03 EP disclosed
EP-3049387-A1 THERMOPLASTIC POLYMER COMPOSITION Milliken & Company (US) 2016-08-03 EP disclosed
EP-3049469-A1 THERMOPLASTIC POLYMER COMPOSITION Milliken & Company (US) 2016-08-03 EP disclosed
EP-3049468-A1 THERMOPLASTIC POLYMER COMPOSITION Milliken & Company (US) 2016-08-03 EP disclosed
US-9200144-B2 Thermoplastic polymer composition MILLIKEN & COMPANY (US) 2015-12-01 US disclosed
US-9200142-B2 Thermoplastic polymer composition MILLIKEN & COMPANY (US) 2015-12-01 US disclosed
US-20080300251-A1 Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors RANBAXY LABORATORIES LIMITED (IN) 2008-12-04 US disclosed
EP-1931633-A2 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS Ranbaxy Laboratories Limited (IN) 2008-06-18 EP disclosed
WO-2007029086-A2 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS RANBAXY LABORATORIES LIMITED (IN) 2007-03-15 WO disclosed
US-20060205772-A1 Amide derivatives and their use as inhibitors of 11-beta-hydroxysteroid dehydrogenase type I COPPOLA GARY M 2006-09-14 US disclosed
CN-1741986-A Amide derivatives and their use as inhibitors of 11-beta hydroxysteroid dehydrogenase NOVARTIS AG (CH) 2006-03-01 CN disclosed
EP-1590319-A1 AMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 Novartis AG (CH) 2005-11-02 EP disclosed
WO-2004065351-A1 AMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 NOVARTIS AG (CH) 2004-08-05 WO disclosed
US-4001218-A BACTERICIDES BAYER AKTIENGESELLSCHAFT (DT) 1977-01-04 US disclosed
US-3982011-A ANTIBIOTICS, ANIMAL GROWTH PROMOTERS BAYER AKTIENGESELLSCHAFT (DT) 1976-09-21 US disclosed
US-3931153-A BACTERICIDE BAYER AKTIENGESELLSCHAFT (DT) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080300251-A1 Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors DPP4, DPP3, DPP8 MITF 3102/4885RAB9A 4093/4885NPC1 1978/4885
US-20060205772-A1 Amide derivatives and their use as inhibitors of 11-beta-hydroxysteroid dehydrogenase type I HSD11B1, HSD11B2, CYP11B1 MITF 2999/4885RAB9A 4227/4885NPC1 1136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.