Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635298 | 0.82 | ALDH1A1 (0.64) | MAPTALDH1A1RECQLUSP2CRHBP | |
| SCHEMBL4896586 | 0.81 | ALDH1A1 (0.60) | MAPTALDH1A1RECQLUSP2CRHBP | |
| SCHEMBL4635251 | 0.71 | CRHBP (0.71) | MAPTALDH1A1CRHBPCRHR2NPC1 | |
| SCHEMBL2005010 | 0.70 | CA12 (0.81) | MAPTALDH1A1RECQLHPGDKMT2A | |
| SCHEMBL6318007 | 0.70 | HPGD (0.74) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL4573407 | 0.70 | HPGD (0.74) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL17319245 | 0.68 | CRHBP (0.77) | MAPTALDH1A1CRHBPCRHR2NPC1 | |
| SCHEMBL15154944 | 0.68 | CRHBP (0.77) | MAPTALDH1A1CRHBPCRHR2NPC1 | |
| SCHEMBL28170795 | 0.66 | MAPT (0.79) | MAPTALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL7565259 | 0.66 | CA1 (0.73) | MAPTALDH1A1HPGDKMT2AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931633-A2 | DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007029086-A2 | DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | disclosed |