Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 8/20 | 0.77 |
| ▸ | CA1 | P00915 | 2/20 | 0.77 |
| ▸ | CA4 | P22748 | 2/20 | 0.77 |
| ▸ | CA6 | P23280 | 2/20 | 0.77 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.77 |
| ▸ | CA2 | P00918 | 1/20 | 0.77 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.77 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.77 |
| ▸ | ITGAL | P20701 | 1/20 | 0.77 |
| ▸ | ADK | P55263 | 1/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL28940073 | 0.91 | AHR (0.71) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL2487163 | 0.91 | AHR (0.71) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL14834292 | 0.90 | AHR (0.68) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL30463845 | 0.88 | — | — | |
| Indole SCHEMBL30250492 | 0.88 | — | — | |
| Indole SCHEMBL28071644 | 0.88 | AHR (1.00) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL29352896 | 0.88 | — | — | |
| Indole SCHEMBL1160186 | 0.88 | AHR (1.00) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL698 | 0.88 | — | — | |
| Indole SCHEMBL27393259 | 0.86 | AHR (0.77) | AHRCA1CA4CA6TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135718-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2019-05-09 | — | — | US | disclosed |
| US-10059664-B2 | Sepiapterin reductase inhibitors for the treatment of pain | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-08-28 | — | — | US | disclosed |
| US-20170305824-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2017-10-26 | — | — | US | disclosed |
| US-9725452-B2 | Substituted indoles and pyrroles as RIP kinase inhibitors | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-08 | — | — | US | disclosed |
| US-9586880-B2 | Small molecule inhibitors of necroptosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-03-07 | — | — | US | disclosed |
| EP-3034494-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-06-22 | — | — | EP | disclosed |
| US-20160102053-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-14 | — | — | US | disclosed |
| EP-3000468-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-03-30 | — | — | EP | disclosed |
| US-20160031812-A1 | SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN | SOLACE PHARMACEUTICALS UK LTD. (GB) | 2016-02-04 | — | — | US | disclosed |
| US-20160024098-A1 | HYBRID NECROPTOSIS INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-01-28 | — | — | US | disclosed |
| US-20120122889-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2012012156-A1 | METHODS AND COMPOSITIONS FOR THE IMPROVEMENT OF SKELETAL MUSCLE FUNCTION IN A MAMMAL | MYOMICS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |
| US-20110144087-A1 | SHORT ACTING BENZOTHIAZEPINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC. (CA) | 2011-06-16 | — | — | US | disclosed |
| EP-2330895-A1 | SHORT ACTING BENZOTHIAZEPINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | Milestone Pharmaceuticals Inc. (CA) | 2011-06-15 | — | — | EP | disclosed |
| WO-2011047156-A1 | SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN | HERCULES TECHNOLOGY MANAGEMENT CO V, INC. (US) | 2011-04-21 | — | — | WO | disclosed |
| US-20100317701-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
| EP-2192838-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-06-09 | — | — | EP | disclosed |
| WO-2010022259-A1 | SHORT ACTING BENZOTHIAZEPINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC. (CA) | 2010-02-25 | — | — | WO | disclosed |
| US-20090099242-A1 | Heterocyclic inhibitors of necroptosis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-04-16 | — | — | US | disclosed |
| WO-2009023272-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031812-A1 | SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN | SPR, QDPR, SRR | AHR 777/4885CA1 4401/4885CA4 4531/4885 |
| US-20120122889-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | AHR 3528/4885CA1 3356/4885CA4 3987/4885 |
| US-20160102053-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | AHR 2014/4885CA1 2546/4885CA4 4182/4885 |
| US-20170305824-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | AHR 3545/4885CA1 3414/4885CA4 3999/4885 |
| US-20100317701-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | AHR 2014/4885CA1 2546/4885CA4 4182/4885 |
| US-20110144087-A1 | SHORT ACTING BENZOTHIAZEPINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | RYR2, ORAI1, RYR1 | AHR 2219/4885CA1 1577/4885CA4 1397/4885 |
| US-20190135718-A1 | SMALL MOLECULE INHIBITORS OF NECROPTOSIS | TNF, TNFRSF1A, RIPK1 | AHR 3545/4885CA1 3414/4885CA4 3999/4885 |
| US-20090099242-A1 | Heterocyclic inhibitors of necroptosis | TNF, RIPK1, RIPK3 | AHR 2014/4885CA1 2546/4885CA4 4182/4885 |
| US-20160024098-A1 | HYBRID NECROPTOSIS INHIBITORS | RIPK3, RIPK1, RIPK4 | AHR 4272/4885CA1 3149/4885CA4 3973/4885 |
| US-10059664-B2 | Sepiapterin reductase inhibitors for the treatment of pain | SPR, QDPR, SRR | AHR 777/4885CA1 4401/4885CA4 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.