N-Ethylmaleimide

N-Ethylmaleimide

SCHEMBL4636622

C=C(C)C.CCN1C(=O)C=CC1=O

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 11/20 0.76
ALDH1A1 P00352 3/20 0.76
BLM P54132 2/20 0.76
LMNA P02545 2/20 0.76
MAPT P10636 2/20 0.76
NPSR1 Q6W5P4 2/20 0.76
GMNN O75496 1/20 0.76
THPO P40225 1/20 0.76
PMP22 Q01453 1/20 0.76
HPGD P15428 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2C19 P33261 1/20 0.45
WRN Q14191 1/20 0.45
HIF1A Q16665 1/20 0.45
GSK3A P49840 3/20 0.44
GSK3B P49841 3/20 0.44
PTGS1 P23219 6/20 0.43
PTGS2 P35354 6/20 0.43
FAAH O00519 4/20 0.43
F2 P00734 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
N-Ethylmaleimide SCHEMBL19666 0.87
N-Ethylmaleimide SCHEMBL18209592 0.87 MGLL (1.00) MGLLALDH1A1BLMLMNAMAPT
N-Ethylmaleimide SCHEMBL28905027 0.85 MGLL (0.94) MGLLALDH1A1BLMLMNAMAPT
N-Ethylmaleimide SCHEMBL3675197 0.82 MGLL (0.89) MGLLALDH1A1BLMLMNAMAPT
N-Ethylmaleimide SCHEMBL8835469 0.81 MGLL (0.76) MGLLALDH1A1BLMLMNAMAPT
N-Ethylmaleimide SCHEMBL28246981 0.81 MGLL (0.76) MGLLALDH1A1BLMLMNAMAPT
N-Ethylmaleimide SCHEMBL28430583 0.80 MGLL (0.84) MGLLALDH1A1BLMLMNAMAPT
N-Ethylmaleimide SCHEMBL9487550 0.80 MGLL (0.84) MGLLALDH1A1BLMLMNAMAPT
N-Ethylmaleimide SCHEMBL4989709 0.78 MGLL (0.80) MGLLALDH1A1BLMLMNAMAPT
N-Ethylmaleimide SCHEMBL28526355 0.78 MGLL (0.80) MGLLALDH1A1BLMLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1309307-B1 HAIR CARE COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS PROCTER & GAMBLE (US) 2006-10-25 EP claimed
US-20060193789-A1 Surfacant, film forming agent, water, gas propellant; plant and animal extracts and oils; may include malathion FOAMIX LTD. (IL) 2006-08-31 US claimed
EP-1205174-B1 Volumising hair treatment composition providing targeted hold to the base of the hair WELLA AG (DE) 2004-08-11 EP claimed
US-6589510-B2 For hair-do or hairstyle WELLA AG (DE) 2003-07-08 US claimed
US-6585965-B1 Hair care compositions comprising polyalkylene glycol styling agents THE PROCTER & GAMBLE COMPANY 2003-07-01 US claimed
EP-1309307-A2 HAIR CARE COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS THE PROCTER & GAMBLE COMPANY (US) 2003-05-14 EP claimed
EP-1309306-A2 WATER-IN-OIL EMULSION COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS THE PROCTER & GAMBLE COMPANY (US) 2003-05-14 EP claimed
US-20020090346-A1 For hair-do or hairstyle Wella GmbH (DE) 2002-07-11 US claimed
WO-2002011685-A2 HAIR CARE COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS THE PROCTER & GAMBLE COMPANY (US) 2002-02-14 WO claimed
WO-2002011684-A2 WATER-IN-OIL EMULSION COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS THE PROCTER & GAMBLE COMPANY (US) 2002-02-14 WO claimed
US-20130189196-A1 Foamable Composition FOAMIX LTD. (IL) 2013-07-25 US disclosed
US-7416567-B2 Cosmetic composition for keratinous substrates with triarylmethane compounds L'OREAL (FR) 2008-08-26 US disclosed
EP-1938791-A2 Cosmetic composition for keratinous substrates containing triarylmethane compounds L'Oréal (FR) 2008-07-02 EP disclosed
US-20080148495-A1 Cosmetic composition for keratinous substrates with triarylmethane compounds L'OREAL (FR) 2008-06-26 US disclosed
EP-1309307-B1 HAIR CARE COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS PROCTER & GAMBLE (US) 2006-10-25 EP disclosed
US-6585965-B1 Hair care compositions comprising polyalkylene glycol styling agents THE PROCTER & GAMBLE COMPANY 2003-07-01 US disclosed
EP-1309307-A2 HAIR CARE COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS THE PROCTER & GAMBLE COMPANY (US) 2003-05-14 EP disclosed
EP-1309306-A2 WATER-IN-OIL EMULSION COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS THE PROCTER & GAMBLE COMPANY (US) 2003-05-14 EP disclosed
WO-2002011685-A2 HAIR CARE COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS THE PROCTER & GAMBLE COMPANY (US) 2002-02-14 WO disclosed
WO-2002011684-A2 WATER-IN-OIL EMULSION COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL STYLING AGENTS THE PROCTER & GAMBLE COMPANY (US) 2002-02-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080148495-A1 Cosmetic composition for keratinous substrates with triarylmethane compounds KRT18, CUTA, TYR MGLL 137/4885ALDH1A1 519/4885BLM 346/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.