Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.44 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.44 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10321961 | 1.00 | DRD2 (0.47) | DRD2DRD3OPRM1KYAT1KYAT3 | |
| SCHEMBL10321639 | 0.87 | DRD2 (0.47) | DRD2DRD3OPRM1KYAT1KYAT3 | |
| SCHEMBL10321638 | 0.87 | DRD2 (0.47) | DRD2DRD3OPRM1KYAT1KYAT3 | |
| SCHEMBL13363972 | 0.84 | DRD2 (0.53) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL9688445 | 0.84 | DRD2 (0.53) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL6395808 | 0.83 | NQO2 (0.41) | ACHESLC6A2SLC6A3 | |
| SCHEMBL7510947 | 0.83 | NQO2 (0.41) | ACHESLC6A2SLC6A3 | |
| SCHEMBL6395804 | 0.83 | NQO2 (0.41) | ACHESLC6A2SLC6A3 | |
| SCHEMBL6395807 | 0.83 | NQO2 (0.41) | ACHESLC6A2SLC6A3 | |
| SCHEMBL13534233 | 0.81 | OPRM1 (0.51) | DRD2DRD3OPRM1HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2484661-B1 | 2,3-DIHYDRO-1H-INDENE-2-YLUREA DERIVATIVE AND PHARMACEUTICAL APPLICATION OF SAME | TORAY INDUSTRIES (JP) | 2017-04-26 | — | — | EP | disclosed |
| US-8653304-B2 | 2,3-dihydro-1H-indene-2-yl urea derivative and pharmaceutical application of same | TORAY INDUSTRIES, INC. (JP) | 2014-02-18 | — | — | US | disclosed |
| EP-2484661-A1 | 2,3-DIHYDRO-1H-INDENE-2-YLUREA DERIVATIVE AND PHARMACEUTICAL APPLICATION OF SAME | Toray Industries, Inc. (JP) | 2012-08-08 | — | — | EP | disclosed |
| US-20120184735-A1 | 2,3-DIHYDRO-1H-INDENE-2-YL UREA DERIVATIVE AND PHARMACEUTICAL APPLICATION OF SAME | TORAY INDUSTRIES, INC. (JP) | 2012-07-19 | — | — | US | disclosed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184735-A1 | 2,3-DIHYDRO-1H-INDENE-2-YL UREA DERIVATIVE AND PHARMACEUTICAL APPLICATION OF SAME | SLC14A1, UROD, UGP2 | DRD2 2824/4885DRD3 2198/4885OPRM1 2297/4885 |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | DRD2 4401/4885DRD3 3808/4885OPRM1 4190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.