Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 11/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.39 |
| ▸ | TNF | P01375 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637258 | 0.83 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637330 | 0.81 | FFAR1 (0.43) | FFAR1KMT2A | |
| SCHEMBL31019693 | 0.72 | SRD5A1 (0.47) | KMT2A | |
| SCHEMBL4637290 | 0.71 | ALDH1A1 (0.51) | FFAR1KMT2A | |
| SCHEMBL8707317 | 0.70 | NR1H3 (0.51) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7425981 | 0.68 | KMT2A (0.47) | FFAR1KMT2A | |
| SCHEMBL3546305 | 0.67 | MTNR1A (0.55) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7424982 | 0.67 | ALDH1A1 (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4637327 | 0.67 | FFAR1 (0.43) | FFAR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4863180 | 0.67 | TNF (0.69) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | claimed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | claimed |
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5728844-A | INHIBITORS OF TUMOR NECROSIS AND PHOSPHODIESTERASE | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |